1,5,6-Trihydroxy-3-methoxyxanthoneCAS# 50868-52-5 |
Quality Control & MSDS
3D structure
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| Cas No. | 50868-52-5 | SDF | Download SDF |
| PubChem ID | 86219227 | Appearance | Powder |
| Formula | C14H10O6 | M.Wt | 274.22 |
| Type of Compound | Xanthones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1,5,6-trihydroxy-3-methoxyxanthen-9-one | ||
| SMILES | COC1=CC(=C2C(=C1)OC3=C(C2=O)C=CC(=C3O)O)O | ||
| Standard InChIKey | JHOYIGDPCIBYKV-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H10O6/c1-19-6-4-9(16)11-10(5-6)20-14-7(12(11)17)2-3-8(15)13(14)18/h2-5,15-16,18H,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 1,5,6-Trihydroxy-3-methoxyxanthone exhibits scavenging activity at 10 uM, it can reduce the viability of HL-60 cells significantly with IC50 values of 28.9 uM. |
| Targets | ROS |
1,5,6-Trihydroxy-3-methoxyxanthone Dilution Calculator
1,5,6-Trihydroxy-3-methoxyxanthone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6467 mL | 18.2335 mL | 36.4671 mL | 72.9341 mL | 91.1677 mL |
| 5 mM | 0.7293 mL | 3.6467 mL | 7.2934 mL | 14.5868 mL | 18.2335 mL |
| 10 mM | 0.3647 mL | 1.8234 mL | 3.6467 mL | 7.2934 mL | 9.1168 mL |
| 50 mM | 0.0729 mL | 0.3647 mL | 0.7293 mL | 1.4587 mL | 1.8234 mL |
| 100 mM | 0.0365 mL | 0.1823 mL | 0.3647 mL | 0.7293 mL | 0.9117 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Chemical constituents of the methanolic extract of leaves of Leiothrix spiralis Ruhland and their antimicrobial activity.[Pubmed:22179427]
Molecules. 2011 Dec 16;16(12):10479-90.
Chemical fractionation of the methanolic extract of leaves of Leiothrix spiralis Ruhland afforded the flavonoids luteolin-6-C-beta-D-glucopyranoside (1), 7-methoxyluteolin-6-C-beta-D-glucopyranoside (2), 7-methoxyluteolin-8-C-beta-D-glucopyranoside (3), 4'-methoxyluteolin-6-C-beta-D-glucopyranoside (4), and 6-hydroxy-7-methoxyluteolin (5), and the xanthones 8-carboxymethyl-1,5,6-Trihydroxy-3-methoxyxanthone (6), 8-carboxy-methyl-1,3,5,6-tetrahydroxyxanthone (7). Methanolic extract, fractions, and isolated compounds of the leaves of L. spiralis were assayed against Gram-positive (Staphylococcus aureus, Bacillus subtilis and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella setubal and Helicobacter pylori) and fungi (the yeasts Candida albicans, C. tropicalis, C. krusei and C. parapsilosis). We observed the best minimum inhibitory concentration values for the methanolic extract against Candida parapsilosis, for the fraction 5 + 6 against Gram-negative bacteria E. coli and P. aeruginosa, and compound 7 against all tested Candida strains. The methanolic extract contents suggest that this species may be a promising source of compounds to produce natural phytomedicines.
Xanthones and flavonoids from Leiothrix curvifolia and Leiothrix flavescens.[Pubmed:11324917]
Phytochemistry. 2001 Apr;56(8):853-6.
8-Carboxymethyl-1,6-dihydroxy-3,5-dimethoxyxanthone, 8-carboxymethyl-1,5,6-Trihydroxy-3-methoxyxanthone and 8-carboxymethyl-1,3,5,6-tetrahydroxyxanthone were isolated from the capitula of Leiothrix curvifolia and Leiothrix flavescens and characterized by spectroscopic methods, mainly 1D and 2D NMR experiments, as well as by electrospray mass spectrometry. Eight known flavonoids were also isolated and they were identified by 1D and 2D NMR experiments and comparison with literature data.
