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1,3,5,6-Tetrahydroxyxanthone

CAS# 5084-31-1

1,3,5,6-Tetrahydroxyxanthone

Catalog No. BCN3453----Order now to get a substantial discount!

Product Name & Size Price Stock
1,3,5,6-Tetrahydroxyxanthone: 5mg $725 In Stock
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Quality Control of 1,3,5,6-Tetrahydroxyxanthone

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Chemical structure

1,3,5,6-Tetrahydroxyxanthone

3D structure

Chemical Properties of 1,3,5,6-Tetrahydroxyxanthone

Cas No. 5084-31-1 SDF Download SDF
PubChem ID 5479774 Appearance Yellow powder
Formula C13H8O6 M.Wt 260.2
Type of Compound Xanthones Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1,3,5,6-tetrahydroxyxanthen-9-one
SMILES C1=CC(=C(C2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O)O
Standard InChIKey CCEBJWKUMKKCDF-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 1,3,5,6-Tetrahydroxyxanthone

The herbs of Canscora decussata

Biological Activity of 1,3,5,6-Tetrahydroxyxanthone

Description1. 1,3,5,6-Tetrahydroxyxanthone can inhibit angiotensin-I-converting-enzyme activity in a dose-dependent manner. 2. 1,3,5,6-Tetrahydroxyxanthone shows moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM against tacrine-induced cytotoxicity in HepG2 cells.

1,3,5,6-Tetrahydroxyxanthone Dilution Calculator

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1,3,5,6-Tetrahydroxyxanthone Molarity Calculator

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Preparing Stock Solutions of 1,3,5,6-Tetrahydroxyxanthone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8432 mL 19.216 mL 38.432 mL 76.864 mL 96.0799 mL
5 mM 0.7686 mL 3.8432 mL 7.6864 mL 15.3728 mL 19.216 mL
10 mM 0.3843 mL 1.9216 mL 3.8432 mL 7.6864 mL 9.608 mL
50 mM 0.0769 mL 0.3843 mL 0.7686 mL 1.5373 mL 1.9216 mL
100 mM 0.0384 mL 0.1922 mL 0.3843 mL 0.7686 mL 0.9608 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 1,3,5,6-Tetrahydroxyxanthone

Chromone glycosides and hepatoprotective constituents of Hypericum erectum.[Pubmed:19898802]

Arch Pharm Res. 2009 Oct;32(10):1393-7.

Two chromone glycosides, hyperimone A [7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM and 217.7 +/- 1.3 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.

Xanthones from roots, hairy roots and cell suspension cultures of selected Hypericum species and their antifungal activity against Candida albicans.[Pubmed:26194328]

Plant Cell Rep. 2015 Nov;34(11):1953-62.

KEY MESSAGE: Highest xanthone contents were found in Hypericum pulchrum and H. annulatum untransformed roots. The best anti- Candida activity was obtained for hairy roots extracts of H. tetrapterum clone 2 ATCC 15834. Extracts of root cultures, hairy roots and cell suspensions of selected Hypericum spp. were screened for the presence of xanthones and tested for their antifungal activity against Candida albicans strain ATCC 10231. At least one of the following xanthones, 5-methoxy-2-deprenylrheediaxanthone; 1,3,6,7-tetrahydroxyxanthone; 1,3,5,6-Tetrahydroxyxanthone; paxanthone; kielcorin or mangiferin was identified in methanolic extracts of the untransformed root cultures. The highest total xanthone content, with five xanthones, was found in untransformed H. pulchrum and H. annulatum root cultures. Hairy roots and the controls of H. tetrapterum contained 1,7-dihydroxyxanthone, while hairy root cultures and the corresponding controls of H. tomentosum contained toxyloxanthone B, 1,3,6,7- and 1,3,5,6-Tetrahydroxyxanthone. Two xanthones, cadensin G and paxanthone, were identified in cell suspension cultures of H. perforatum. Their content increased about two-fold following elicitation with salicylic acid. The anti-Candida activity of the obtained extracts ranged from MIC 64 to >256 microg ml(-1). Among the extracts of Hypericum untransformed roots, the best antifungal activity was obtained for extracts of H. annulatum grown under CD conditions. Extracts of hairy roots clones A4 and 7 ATCC15834 of H. tomentosum and clone 2 ATCC15834 of H. tetrapterum displayed inhibition of 90% of Candida growth with 256 mug ml(-1). Extracts from chitosan-elicitated cells did not show antifungal activity.

Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterospermum lanceolatum.[Pubmed:1517742]

J Nat Prod. 1992 May;55(5):691-5.

Five tetrahydroxyxanthones, 3,4,6,7-tetrahydroxyxanthone [1], 1,3,5,6-Tetrahydroxyxanthone [2], 3,4,5,6-tetrahydroxyxanthone [3], 1,3,6,7-tetrahydroxyxanthone [4], and 2,3,6,7-tetrahydroxyxanthone [5] isolated from Tripterospermum lanceolatum inhibited angiotensin-I-converting-enzyme activity in a dose-dependent manner. The mode of inhibition of the tetrahydroxyxanthones (THXs) was found to be competitive inhibition. When the tetrahydroxy groups of THXs were blocked with acetyl groups, the angiotensin-I-converting-enzyme inhibitory activity was abolished, suggesting that the tetrahydroxy groups are indispensible for the inhibitory activity.

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