Tetramisole HClCAS# 5086-74-8 |
Quality Control & MSDS
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| Cas No. | 5086-74-8 | SDF | Download SDF |
| PubChem ID | 68628 | Appearance | Powder |
| Formula | C11H13ClN2S | M.Wt | 240.75 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | (±)-Tetramisole hydrochloride; DL-Tetramisole hydrochloride; R-829 | ||
| Solubility | H2O : 100 mg/mL (415.37 mM; Need ultrasonic) DMSO : 10 mg/mL (41.54 mM; Need ultrasonic) | ||
| Chemical Name | 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride | ||
| SMILES | [H+].[Cl-].C1CN2CC(N=C2S1)c3ccccc3 | ||
| Standard InChIKey | LAZPBGZRMVRFKY-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Tetramisole hydrochloride is an inhibitor of alkaline phosphatases, is a high purity antiparasitic. |
Tetramisole HCl Dilution Calculator
Tetramisole HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.1537 mL | 20.7684 mL | 41.5369 mL | 83.0737 mL | 103.8422 mL |
| 5 mM | 0.8307 mL | 4.1537 mL | 8.3074 mL | 16.6147 mL | 20.7684 mL |
| 10 mM | 0.4154 mL | 2.0768 mL | 4.1537 mL | 8.3074 mL | 10.3842 mL |
| 50 mM | 0.0831 mL | 0.4154 mL | 0.8307 mL | 1.6615 mL | 2.0768 mL |
| 100 mM | 0.0415 mL | 0.2077 mL | 0.4154 mL | 0.8307 mL | 1.0384 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Tetramisole is a mixture of dextro- and levo isomers used as an anthelmintic.
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Quantification of the histochemical reaction for alkaline phosphatase activity using the indoxyl-tetranitro BT method.[Pubmed:2438256]
Histochem J. 1987 Feb;19(2):94-102.
The indoxyl-tetranitro BT method for the demonstration of alkaline phosphatase activity has been optimized and its validity for quantitative histochemistry tested. The study has been performed with model films of polyacrylamide gel incorporating homogenate of rat liver and with cryostat sections from the same livers. Addition of polyvinyl alcohol to the incubation medium greatly improved the localization of the final reaction product in cryostat sections. In polyacrylamide films, the formazan production specifically due to alkaline phosphatase was highest when using a medium containing 100 mM Tris-HCl buffer, pH 9.0, 0.2-1.0 mM substrate, 0.32 mM 1-methoxyphenazine methosulphate, 10 mM MgCl2, 5 mM sodium azide and 1 mM tetranitro BT. For the incubation of cryostat sections in the presence of polyvinyl alcohol, the same medium could be used but the optimum concentrations of substrate and tetranitro BT appeared to be 1-2 mM and 5 mM respectively. The test minus control reaction was specific for alkaline phosphatase activity and could be inhibited completely with tetramisole. The test minus control reaction was linear with time up to 30 min with model films and up to 15 min with cryostat sections. The formazan production was also linear with the amount of homogenate incorporated in model films and with section thickness up to 18 micron and therefore, the reaction obeyed the Beer-Lambert law. Variation of the substrate concentration yielded a KM of 0.05 mM for aqueous media and a KM of 0.55 mM for polyvinyl alcohol-containing media.(ABSTRACT TRUNCATED AT 250 WORDS)
