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1-Acetoxy-5-deacetylbaccatin I

CAS# 119120-27-3

1-Acetoxy-5-deacetylbaccatin I

Catalog No. BCN6357----Order now to get a substantial discount!

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1-Acetoxy-5-deacetylbaccatin I: 5mg $92 In Stock
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Quality Control of 1-Acetoxy-5-deacetylbaccatin I

Number of papers citing our products

Chemical structure

1-Acetoxy-5-deacetylbaccatin I

3D structure

Chemical Properties of 1-Acetoxy-5-deacetylbaccatin I

Cas No. 119120-27-3 SDF Download SDF
PubChem ID 102004901 Appearance Cryst.
Formula C32H44O14 M.Wt 652.7
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(1'S,2R,2'S,3'R,5'S,7'S,8'S,9'R,10'R,13'S)-1',2',9',10',13'-pentaacetyloxy-5'-hydroxy-8',12',15',15'-tetramethylspiro[oxirane-2,4'-tricyclo[9.3.1.03,8]pentadec-11-ene]-7'-yl] acetate
SMILES CC1=C2C(C(C3(C(CC(C4(C3C(C(C2(C)C)(CC1OC(=O)C)OC(=O)C)OC(=O)C)CO4)O)OC(=O)C)C)OC(=O)C)OC(=O)C
Standard InChIKey YUGIEMWECOIFRK-MBMCFSISSA-N
Standard InChI InChI=1S/C32H44O14/c1-14-21(41-15(2)33)12-32(46-20(7)38)28(45-19(6)37)26-30(10,23(42-16(3)34)11-22(39)31(26)13-40-31)27(44-18(5)36)25(43-17(4)35)24(14)29(32,8)9/h21-23,25-28,39H,11-13H2,1-10H3/t21-,22-,23-,25+,26-,27-,28-,30+,31+,32+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 1-Acetoxy-5-deacetylbaccatin I

The barks of Taxus chinensis

Biological Activity of 1-Acetoxy-5-deacetylbaccatin I

In vitro

Studies on the chemical constituents of Taxus yunnanensis.[Pubmed: 1688071 ]

Yao Xue Xue Bao. 1991;26(10):747-54.


METHODS AND RESULTS:
From this extract eight taxane diterpenoids and taxane alkaloids have been isolated. Seven of them have been identified as taxinine E(1), taxinine J(2), 1-Acetoxy-5-deacetylbaccatin I(4), baccatin III(5), taxol (6), cephalomannine (7), 7-xylosyl-10-deacetyl taxol (8) from their physical and spectroscopic properties. A new taxane diterpenoid, named yunnanxane (3) was elucidated as taxa-4 (20), 11-diene-2 alpha, 5 alpha, 10 beta, 14 beta-tetraoln2 alpha,5 alpha,10 beta-triacetaten-14 beta-alpha-methyl-beta- hydroxylbutyratebyhighfield 1H NMR, 13C NMR, 1H-1HCOSY, 13C-1HCOSY, 13C-1HCOLOC and X-ray analysis.
CONCLUSIONS:
It showed the inhibitory effect on A2780 DDP, KB and HCT-8 cell line in vitro. All of the eight compounds were isolated from this species for the first time.

1-Acetoxy-5-deacetylbaccatin I Dilution Calculator

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1-Acetoxy-5-deacetylbaccatin I Molarity Calculator

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Preparing Stock Solutions of 1-Acetoxy-5-deacetylbaccatin I

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5321 mL 7.6605 mL 15.321 mL 30.6419 mL 38.3024 mL
5 mM 0.3064 mL 1.5321 mL 3.0642 mL 6.1284 mL 7.6605 mL
10 mM 0.1532 mL 0.766 mL 1.5321 mL 3.0642 mL 3.8302 mL
50 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.6128 mL 0.766 mL
100 mM 0.0153 mL 0.0766 mL 0.1532 mL 0.3064 mL 0.383 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 1-Acetoxy-5-deacetylbaccatin I

[Studies on the chemical constituents of Taxus yunnanensis].[Pubmed:1688071]

Yao Xue Xue Bao. 1991;26(10):747-54.

The ethanolic extract of the bark of Taxus yunnanensis Cheng et L. K. Fu. showed significant antineoplastic effect on the transplantable tumors in mice. The life survival of P388 leukemic bearing mice was increased (84%) and the growth of B16 melanoma in mice was inhibited (53%). From this extract eight taxane diterpenoids and taxane alkaloids have been isolated. Seven of them have been identified as taxinine E(1), taxinine J(2), 1-acetoxy-5-deacetyl baccatin I(4), baccatin III(5), taxol (6), cephalomannine (7), 7-xylosyl-10-deacetyl taxol (8) from their physical and spectroscopic properties. A new taxane diterpenoid, named yunnanxane (3) was elucidated as taxa-4 (20), 11-diene-2 alpha, 5 alpha, 10 beta, 14 beta-tetraoln2 alpha,5 alpha,10 beta-triacetaten-14 beta-alpha-methyl-beta- hydroxylbutyratebyhighfield 1H NMR, 13C NMR, 1H-1HCOSY, 13C-1HCOSY, 13C-1HCOLOC and X-ray analysis. It showed the inhibitory effect on A2780 DDP, KB and HCT-8 cell line in vitro. All of the eight compounds were isolated from this species for the first time.

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