Taxumairol B

New taxane diterpenoids from the roots of Taxus mairei.[Pubmed: 8991951 ]

J Nat Prod. 1996 Feb;59(2):173-6.

METHODS AND RESULTS:
Two new taxoids, taxumairol A (1) and Taxumairol B (2), have been isolated from extracts of the roots of Formosan Taxus mairei (Lemee & Levl.) S. Y. Hu. The structures of 1 and 2 were identified as 5 alpha, 7 beta, 9 alpha, 10 beta, 13 alpha-pentaacetoxy-20-(benzoyloxy)- 2 alpha, 4 alpha-dihydroxytax-11-ene and 2 alpha, 5 alpha, 10 beta,-13 alpha-tetraacetoxy-1 beta, 7 beta, 9 alpha-trihydroxy-4 beta,20-epoxytax-11-ene, primarily on the basis of 1D- and 2D-NMR techniques including DEPT, COSY, and HMBC experiments, as well as chemical correlation with known compounds.
CONCLUSIONS:
Taxumairol A (1) exhibited significant cytotoxicities against murine P-388 and human KB-16, A-549, and HT-29 tumor cell lines.

Chinese Traditional & Herbal Drugs, 2013, 44(11):1380-1385.

Chemical constituents from seeds of Taxus yunnanensis.[Reference: WebLink]

To study the chemical constituents from the seeds of Taxus yunnanensis.
METHODS AND RESULTS:
The chemical constituents in the seeds of T. yunnanensis were isolated by chromatography and identified by a comprehensive analysis on the spectral data. Twelve taxanes were isolated from the seeds of T. yunnanensis and identified as 7-epi-10-deacetyltaxol (1), 2-deacetoxytaxuspine C (2), 9α-hydroxy-2α, 7α, 10β-triacetoxy-5α-cinnamoyloxy-3, 11-cyclotaxa-4(20)-en-13-one (3), 2α-acetoxy-5α-cinnamoyloxy-9α, 10β-dihydroxy-taxa-4 (20), 11-diene-13-one (4), dantaxusin C (5), taxezopidine H (6), 9-deacetyltaxinine A (7), 5α-decinnamoyltaxagifine (8), Taxumairol B (9), 2α, 5α, 13α-trihydroxy-7β, 9α, 10β-triacetoxy-taxa-4(20), 11-diene (10), 7, 9, 10, 13-tetra-O-deacetylabeobaccatin VI (11), and taxacustin (12).
CONCLUSIONS:
Compounds 2, 3, and 7-12 are isolated from T. yunnanensis for the first time.