Shizukaol CCAS# 142279-41-2 |
Quality Control & MSDS
3D structure
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| Cas No. | 142279-41-2 | SDF | Download SDF |
| PubChem ID | 71591590 | Appearance | Powder |
| Formula | C36H42O10 | M.Wt | 634.7 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(1R,2S,8R,9S,10S,12R,13S,14S,17S,19R,20S,21R,23Z)-9,21-dihydroxy-5-(hydroxymethyl)-23-(1-methoxy-1-oxopropan-2-ylidene)-13,20-dimethyl-4,22-dioxo-3-oxaoctacyclo[14.7.1.02,6.02,14.08,13.010,12.017,19.020,24]tetracosa-5,16(24)-dien-9-yl]methyl (E)-2-methylbut-2-enoate | ||
| SMILES | CC=C(C)C(=O)OCC1(C2CC2C3(C1CC4=C(C(=O)OC45C3CC6=C7C5C(=C(C)C(=O)OC)C(=O)C(C7(C8C6C8)C)O)CO)C)O | ||
| Standard InChIKey | KDKIOCIPCJDWMT-ADSFGAOYSA-N | ||
| Standard InChI | InChI=1S/C36H42O10/c1-7-14(2)30(40)45-13-35(43)22-10-21(22)33(4)23(35)11-20-18(12-37)32(42)46-36(20)24(33)9-17-16-8-19(16)34(5)26(17)27(36)25(28(38)29(34)39)15(3)31(41)44-6/h7,16,19,21-24,27,29,37,39,43H,8-13H2,1-6H3/b14-7+,25-15-/t16-,19-,21-,22+,23-,24+,27+,29+,33+,34+,35+,36+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Chloranthus japonicus
| Description | 1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. 2. Shizukaol C has significant cytotoxicities against C8166 cells. |
| Targets | HIV |
Shizukaol C Dilution Calculator
Shizukaol C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5755 mL | 7.8777 mL | 15.7555 mL | 31.511 mL | 39.3887 mL |
| 5 mM | 0.3151 mL | 1.5755 mL | 3.1511 mL | 6.3022 mL | 7.8777 mL |
| 10 mM | 0.1576 mL | 0.7878 mL | 1.5755 mL | 3.1511 mL | 3.9389 mL |
| 50 mM | 0.0315 mL | 0.1576 mL | 0.3151 mL | 0.6302 mL | 0.7878 mL |
| 100 mM | 0.0158 mL | 0.0788 mL | 0.1576 mL | 0.3151 mL | 0.3939 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.[Pubmed:21650224]
J Nat Prod. 2011 Jun 24;74(6):1408-13.
Five new lindenane disesquiterpenoids, chlorajaponilides A-E (1-5), together with 11 known analogues were isolated from whole plants of Chloranthus japonicus. The structure and absolute configuration of 1 was confirmed by X-ray crystallography. Compounds 1 and 2 represent the first examples of lindenane disesquiterpenoids with a C-5 hydroxy group and a C-4-C-15 double bond. Compounds 8, 9, 11, and 12 showed anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. Shizukaol B (8) exhibited the best activity against HIV(wt), HIV(RT-K103N), and HIV(RT-K103N) with EC(5)(0) values of 0.22, 0.47, and 0.50 muM, respectively. Compounds 8, 9, 11, and 12 had significant cytotoxicities against C8166 cells with CC(5)(0) values of 0.020, 0.089, 0.047, and 0.022, respectively, and exhibited inhibitory activities against HIV-1 with EC(5)(0) values of 0.0014, 0.016, 0.0043, and 0.0033 muM, respectively.
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