2,3',4,6-TetrahydroxybenzophenoneCAS# 26271-33-0 |
Quality Control & MSDS
3D structure
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| Cas No. | 26271-33-0 | SDF | Download SDF |
| PubChem ID | 440991 | Appearance | Yellow powder |
| Formula | C13H10O5 | M.Wt | 246.2 |
| Type of Compound | Xanthones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3-hydroxyphenyl)-(2,4,6-trihydroxyphenyl)methanone | ||
| SMILES | C1=CC(=CC(=C1)O)C(=O)C2=C(C=C(C=C2O)O)O | ||
| Standard InChIKey | QWRYPHZJTWQLFX-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 2,3',4,6-Tetrahydroxybenzophenone possesses significant antioxidant activity. |
| Targets | P450 (e.g. CYP17) |
2,3',4,6-Tetrahydroxybenzophenone Dilution Calculator
2,3',4,6-Tetrahydroxybenzophenone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0617 mL | 20.3087 mL | 40.6174 mL | 81.2348 mL | 101.5435 mL |
| 5 mM | 0.8123 mL | 4.0617 mL | 8.1235 mL | 16.247 mL | 20.3087 mL |
| 10 mM | 0.4062 mL | 2.0309 mL | 4.0617 mL | 8.1235 mL | 10.1543 mL |
| 50 mM | 0.0812 mL | 0.4062 mL | 0.8123 mL | 1.6247 mL | 2.0309 mL |
| 100 mM | 0.0406 mL | 0.2031 mL | 0.4062 mL | 0.8123 mL | 1.0154 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum L.[Pubmed:9459298]
FEBS Lett. 1997 Dec 29;420(2-3):143-6.
The biosynthesis of xanthones was studied in cell cultures of Hypericum androsaemum L. We have detected a new benzophenone synthase, for which the preferred substrate is benzoyl-CoA, itself supplied by 3-hydroxybenzoate:coenzyme A ligase. The stepwise condensation of benzoyl-CoA with three molecules of malonyl-CoA, catalyzed by benzophenone synthase, yields 2,4,6-trihydroxybenzophenone. This intermediate is subsequently converted by benzophenone 3'-hydroxylase, a cytochrome P450 monooxygenase. These biosynthetic steps, leading to the formation of 2,3',4,6-tetrahydroxybenzophenone, represent an alternative pathway to that recently proposed for cell cultures of Centaurium erythraea [Peters et al., Planta (1997) in press].
Cytotoxic benzophenone and triterpene from Garcinia hombroniana.[Pubmed:24813683]
Bioorg Chem. 2014 Jun;54:60-7.
Garcinia hombroniana (seashore mangosteen) in Malaysia is used to treat itching and as a protective medicine after child birth. This study was aimed to investigate the bioactive chemical constituents of the bark of G. hombroniana. Ethyl acetate and dichloromethane extracts of G. hombroniana yielded two new (1, 9) and thirteen known compounds which were characterized by the spectral techniques of NMR, UV, IR and EI/ESI-MS, and identified as; 2,3',4,5'-tetrahydroxy-6-methoxybenzophenone(1), 2,3',4,4'-tetrahydroxy-6-methoxybenzophenone (2), 2,3',4,6-tetrahydroxybenzophenone (3), 1,3,6,7-tetrahydroxyxanthone (4), 3,3',4',5,7-pentahydroxyflavone (5),3,3',5,5',7-pentahydroxyflavanone (6), 3,3',4',5,5',7-hexahydroxyflavone (7), 4',5,7-trihydroxyflavanone-7-rutinoside (8), 18(13-->17)-abeo-3beta-acetoxy-9alpha,13beta-lanost-24E-en-26-oic acid (9), garcihombronane B (10), garcihombronane D (11), friedelan-3-one (12), lupeol (13), stigmasterol (14) and stigmasterol glucoside (15). In the in vitro cytotoxicity against MCF-7, DBTRG, U2OS and PC-3 cell lines, compounds 1 and 9 displayed good cytotoxic effects against DBTRG cancer cell lines. Compounds 1-8 were also found to possess significant antioxidant activities. Owing to these properties, this study can be further extended to explore more significant bioactive components of this plant.
