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2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one

CAS# 1809980-25-3

2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one

2D Structure

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2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one

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Chemical Properties of 2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one

Cas No. 1809980-25-3 SDF Download SDF
PubChem ID N/A Appearance Powder
Formula C18H24O5 M.Wt 320.4
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one

The herbs of Curcuma phaeocaulis

Protocol of 2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one

Structure Identification
Chinese Journal of Medicinal Chemistry, 2015.

Isolation and identification of terpenoids from Myrrh.[Reference: WebLink]


METHODS AND RESULTS:
The chemical constituents from the CHCl3 extract of Commiphora opobalsamum were isolated and purified by various kind of column chromatography on silica gel,Sephadex LH-20 and ODS,and their structures were elucidated by the physico-chemical characters and the spectroscopic analysis. Twelve compounds were obtained and identified as proximadiol( 1),orientalol E( 2),alismol( 3),guaianediol( 4),( 1( 10) E,2R*,4R*,5S*)-2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one( 5),( 1( 10) E,2R*,4R*)-2- methoxy-8,12-epoxygermacra-1( 10),7,11-trien-6-one( 6),myrrhone( 7),dihydropyrocurzerenone( 8),cycloartane-1α,2α,3β,25-tetrol( 9),cycloartan-24-ene-1α,2α,3β-triol( 10),cycloartan-24-ene-1α,3β-diol( 11),and 29-norlanost-8,24-dien-1α,2α,3β-triol( 12),respectively. Compounds 1- 3 were isolated from Commiphora for the first time. All the isolated compounds were evaluated for their cytotoxicity against the PC-3hunman prostate tumor cell line.
CONCLUSIONS:
Only compounds 10 and 12 exhibited weak cytoxicity with IC50 values of37. 4 μmol·L~(-1),26. 2 μmol·L~(-1),respectively.

2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one Dilution Calculator

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Preparing Stock Solutions of 2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1211 mL 15.6055 mL 31.211 mL 62.422 mL 78.0275 mL
5 mM 0.6242 mL 3.1211 mL 6.2422 mL 12.4844 mL 15.6055 mL
10 mM 0.3121 mL 1.5605 mL 3.1211 mL 6.2422 mL 7.8027 mL
50 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.2484 mL 1.5605 mL
100 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.6242 mL 0.7803 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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