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Methyl neochebulinate

CAS# 1236310-34-1

Methyl neochebulinate

2D Structure

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Methyl neochebulinate

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Chemical Properties of Methyl neochebulinate

Cas No. 1236310-34-1 SDF Download SDF
PubChem ID N/A Appearance Powder
Formula C42H36O28 M.Wt 988.7
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Methyl neochebulinate

The fruits of Phyllanthus emblica

Protocol of Methyl neochebulinate

Kinase Assay

Hydrolyzable tannins from the fruits of Terminalia chebula Retz and their α-glucosidase inhibitory activities.[Pubmed: 28213992 ]

Phytochemistry. 2017 May;137:109-116.


METHODS AND RESULTS:
Nine hydrolyzable tannins, including three previously unknown and six artifacts, were isolated, together with thirty-nine known ones, from the fruits of Terminalia chebula Retz. (Combretaceae). They were identified as 1,2,3-tri-O-galloyl-6-O-cinnamoyl-β-d-glucose, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-β-d-glucose, 4-O-(2″,4″-di-O-galloyl-α-l-rhamnosyl)ellagic acid, 1'-O-methyl neochebulanin, diMethyl neochebulinate, 6'-O-methyl neochebulagate, dimethyl neochebulagate, dimethyl 4'-epi-neochebulagate, and methyl chebulagate by the spectroscopic interpretation.
CONCLUSIONS:
After evaluation for α-glucosidase inhibition of all isolated compounds, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-β-d-glucose and 4-O-(2″,4″-di-O-galloyl-α-l-rhamnosyl)ellagic acid showed significant inhibitory activities with IC50 values of 2.9 and 6.4 μM, respectively. In addition, inhibition kinetic studies showed that both compounds have mixed-type inhibitory activities with the inhibition constants (Ki) of 1.9 and 4.0 μM, respectively.

Methyl neochebulinate Dilution Calculator

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Methyl neochebulinate Molarity Calculator

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Preparing Stock Solutions of Methyl neochebulinate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.0114 mL 5.0571 mL 10.1143 mL 20.2286 mL 25.2857 mL
5 mM 0.2023 mL 1.0114 mL 2.0229 mL 4.0457 mL 5.0571 mL
10 mM 0.1011 mL 0.5057 mL 1.0114 mL 2.0229 mL 2.5286 mL
50 mM 0.0202 mL 0.1011 mL 0.2023 mL 0.4046 mL 0.5057 mL
100 mM 0.0101 mL 0.0506 mL 0.1011 mL 0.2023 mL 0.2529 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Methyl neochebulinate

Hydrolyzable tannins from the fruits of Terminalia chebula Retz and their alpha-glucosidase inhibitory activities.[Pubmed:28213992]

Phytochemistry. 2017 May;137:109-116.

Nine hydrolyzable tannins, including three previously unknown and six artifacts, were isolated, together with thirty-nine known ones, from the fruits of Terminalia chebula Retz. (Combretaceae). They were identified as 1,2,3-tri-O-galloyl-6-O-cinnamoyl-beta-d-glucose, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-beta-d-glucose, 4-O-(2'',4''-di-O-galloyl-alpha-l-rhamnosyl)ellagic acid, 1'-O-methyl neochebulanin, diMethyl neochebulinate, 6'-O-methyl neochebulagate, dimethyl neochebulagate, dimethyl 4'-epi-neochebulagate, and methyl chebulagate by the spectroscopic interpretation. After evaluation for alpha-glucosidase inhibition of all isolated compounds, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-beta-d-glucose and 4-O-(2'',4''-di-O-galloyl-alpha-l-rhamnosyl)ellagic acid showed significant inhibitory activities with IC50 values of 2.9 and 6.4 muM, respectively. In addition, inhibition kinetic studies showed that both compounds have mixed-type inhibitory activities with the inhibition constants (Ki) of 1.9 and 4.0 muM, respectively.

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