Ginsenoside MC

CAS# 175484-06-7

Ginsenoside MC

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Quality Control of Ginsenoside MC

Number of papers citing our products

Chemical structure

Ginsenoside MC

Chemical Properties of Ginsenoside MC

Cas No. 175484-06-7 SDF Download SDF
PubChem ID N/A Appearance Powder
Formula C41H70O12 M.Wt 755.0
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ginsenoside MC

The roots of Panax ginseng C. A. Mey.

Biological Activity of Ginsenoside MC

DescriptionGinsenoside MC exhibits potent antitumor activity. Ginsenoside MC has improving anti-aging, anti-acne, anti-inflammatory, anti-microbial and moisturizing effects and promoting hair growth and anti-dandruff effect.
In vitro

Topical compositions comprising ginsenoside Mc with anti-aging and hair growth-promoting effects.[Reference: WebLink]

MOREPACIFIC Corp., S. Korea .,2014,23pp


METHODS AND RESULTS:
The present invention relates to a skin external compn. comprising Ginsenoside MC for for improving anti-aging, anti-acne, anti-inflammatory, anti-microbial and moisturizing effects and promoting hair growth and anti-dandruff effect.

Transformation of bioactive compounds by Fusarium sacchari fungus isolated from the soil-cultivated ginseng.[Reference: WebLink]

Journal of Agricultural and Food Chemistry, 2007, 55(23):9373-9379.

Ginsenoside bioactive compounds, namely, compound K (C-K), compound Mx (C-Mx), and Ginsenoside MC (G-Mc), were the metabolites of ginsenosides Rb 1, Rb 2, Rb 3, and Rc by intestinal microflora of humans or rats, microorganisms, and enzymes, and C-K showed beneficial effects in vitro and in vivo as an antitumoral agent. The objective of this work was to explore an efficient procedure for biotransformation of these bioactive compounds.
METHODS AND RESULTS:
Thus, a filamentous fungus, Fusarium sacchari, was first obtained from the soil-cultivated ginseng, which was verified to possess a potent capacity of transformation of C-K, C-Mx, and G-Mc. The optimal biotransformation conditions of F. sacchari with C-K, C-Mx, and G-Mc were obtained as follows: transforming temperature, 30 degrees C; transforming time, 6 days; rotary speed, 160 rpm; pH of the medium, 5.5. HPLC analysis indicated that these three bioactive compounds were key metabolites and their structures were confirmed by (1)H and (13)C NMR analysis. Moreover, the in vitro antitumor activities of C-K, C-Mx, and G-Mc and the in vivo antitumor activities of the transformed product mainly containing these compounds were also evaluated.
CONCLUSIONS:
Among C-K, C-Mx, and G-Mc, C-K exhibited the most potent antitumor activities. The in vivo study showed that the transformed products by F. sacchari had much more antitumor activity than those of commonly used ginsenoside Rg3 and Paclitaxel.

Ginsenoside MC Dilution Calculator

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Ginsenoside MC Molarity Calculator

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Preparing Stock Solutions of Ginsenoside MC

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3245 mL 6.6225 mL 13.245 mL 26.4901 mL 33.1126 mL
5 mM 0.2649 mL 1.3245 mL 2.649 mL 5.298 mL 6.6225 mL
10 mM 0.1325 mL 0.6623 mL 1.3245 mL 2.649 mL 3.3113 mL
50 mM 0.0265 mL 0.1325 mL 0.2649 mL 0.5298 mL 0.6623 mL
100 mM 0.0132 mL 0.0662 mL 0.1325 mL 0.2649 mL 0.3311 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ginsenoside MC

[Studies on chemical constituents of saponins from Panax ginseng flower buds].[Pubmed:31359719]

Zhongguo Zhong Yao Za Zhi. 2019 Jun;44(12):2519-2531.

This project is to investigate the chemical constituents of ginsenosides from the flower buds of Panax ginseng. The compounds were isolated by using a variety of chromatographic methods including Diaion HP-20,silica gel,MCI gel and semi-preparative HPLC chromatography. Their structures were identified by NMR,and MS data. As a result,32 compounds were isolated from the extract of P. ginseng flower buds,and identified as ginsenoside Rk_3( 1),ginsenoside Rh_4( 2),ginsenoside Rh_8( 3),pseudoginsenoside Rc_1( 4),ginsenoside Rc( 5),ginsenoside Rb_2( 6),ginsenoside Rg_6( 7),20( E)-ginsenoside F_4( 8),ginsenoside Rb_1( 9),vinaginsenoside R_(16)( 10),ginsenoside Rh_6( 11),vinaginsenoside R_3( 12),5,6-didehydro-ginsenoside Rd( 13),vinaginsenoside R_4( 14),vinaginsenoside R_8( 15),ginsenoside Rf( 16),notoginsenoside E( 17),ginsenoside ( 18),3-O-beta-D-glucopyranosyl-3beta,7beta,12beta,20 S-tetrahydroxydammar-5( 6),24-diene-20-O-beta-D-glucopyranoside( 19),20( S)-ginsenoside Rg_2( 20),20( R)-ginsenoside Rg_2( 21),notoginsenoside R_2( 22),ginsenoside F_2( 23),quinquenoside I( 24),ginsenoside M_1( 25),quinquenoside L_(10)( 26),ginsenoside Rh_5( 27),ginsenoside Rg_5( 28),ginsenoside Rk_1( 29),20( R)-ginsenoside Rg_3( 30),oleanolic acid 3-O-beta-D-glucopyranosyl-( 1-->2)-beta-D-( 6'-methyl ester)-glucuronopyranoside( 31) and Ginsenoside MC( 32). Among them,compounds 10,12,13,15,19,22,24,31 and 32 were isolated from P. ginseng for the first time,and compound 19 was a genuine ginsenoside firstly obtained by separation and identification,with NMR data that were also reported. Compounds 1-3,7,8,23,25-30 were isolated from P. ginseng flower buds for the first time.

Transformation of bioactive compounds by Fusarium sacchari fungus isolated from the soil-cultivated ginseng.[Pubmed:17935295]

J Agric Food Chem. 2007 Nov 14;55(23):9373-9.

Ginsenoside bioactive compounds, namely, compound K (C-K), compound Mx (C-Mx), and Ginsenoside MC (G-Mc), were the metabolites of ginsenosides Rb 1, Rb 2, Rb 3, and Rc by intestinal microflora of humans or rats, microorganisms, and enzymes, and C-K showed beneficial effects in vitro and in vivo as an antitumoral agent. The objective of this work was to explore an efficient procedure for biotransformation of these bioactive compounds. Thus, a filamentous fungus, Fusarium sacchari, was first obtained from the soil-cultivated ginseng, which was verified to possess a potent capacity of transformation of C-K, C-Mx, and G-Mc. The optimal biotransformation conditions of F. sacchari with C-K, C-Mx, and G-Mc were obtained as follows: transforming temperature, 30 degrees C; transforming time, 6 days; rotary speed, 160 rpm; pH of the medium, 5.5. HPLC analysis indicated that these three bioactive compounds were key metabolites and their structures were confirmed by (1)H and (13)C NMR analysis. Moreover, the in vitro antitumor activities of C-K, C-Mx, and G-Mc and the in vivo antitumor activities of the transformed product mainly containing these compounds were also evaluated. Among C-K, C-Mx, and G-Mc, C-K exhibited the most potent antitumor activities. The in vivo study showed that the transformed products by F. sacchari had much more antitumor activity than those of commonly used ginsenoside Rg3 and Paclitaxel.

Inhibition of intracerebroventricular injection stress-induced plasma corticosterone levels by intracerebroventricularly administered compound K, a ginseng saponin metabolite, in mice.[Pubmed:12843635]

Biol Pharm Bull. 2003 Jul;26(7):1035-8.

Effects of major intestinal metabolites of ginsenosides, including compound K (IH-901, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol), compound Y (IH-902, 20-O-[alpha-L-arabinopyranosyl (1-->6)-beta-D-glucopyranosyl]-20(S)-protopanaxadiol), and Ginsenoside MC (IH-903, 20-O-[alpha-L-arabinofuranosyl (1-->6)-beta-D-glucopyranosyl]-20(S)-protopanaxadiol), on acute stress-induced plasma corticosterone levels were studied in mice. Intracerebroventricularly (i.c.v.) administered compound K (1 microg) attenuated the i.c.v. injection stress-induced increase in plasma corticosterone level, and this inhibitory effect was not affected by co-administered N(G)-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor. Compound K administered intraperitoneally affected neither the i.c.v. injection stress- nor the immobilization stress-induced increase in plasma corticosterone levels. Compound K and Ginsenoside MC did not affect plasma corticosterone levels induced by the two stress modalities used in this study.

[Saponins with low sugar chain from the leaves of Panax notoginseng (Burk) F. H. Chen].[Pubmed:12583159]

Zhong Yao Cai. 2002 Mar;25(3):176-8.

Six saponins with low sugar chain were isolated from the leaves of Panax notoginseng (Burk) F. H. Chen. Their structures were elucidated as 20(R)-ginsenoside Rh2(I), 20(R)-ginsenoside Rg3(II), Ginsenoside MC(III), ginsenoside F1(IV), ginsenoside Rh1(V) and daucosterol(VI) by spectroscopic analysis and comparison with authentic samples. Compounds I-IV were first isolated from the plant.

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