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(E)-6-O-(p-coumaroyl)scandoside methyl ester

CAS# 83946-90-1

(E)-6-O-(p-coumaroyl)scandoside methyl ester

Catalog No. BCN8902----Order now to get a substantial discount!

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(E)-6-O-(p-coumaroyl)scandoside methyl ester: 5mg $127 In Stock
(E)-6-O-(p-coumaroyl)scandoside methyl ester: 10mg Please Inquire In Stock
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Quality Control of (E)-6-O-(p-coumaroyl)scandoside methyl ester

Number of papers citing our products

Chemical structure

(E)-6-O-(p-coumaroyl)scandoside methyl ester

3D structure

Chemical Properties of (E)-6-O-(p-coumaroyl)scandoside methyl ester

Cas No. 83946-90-1 SDF Download SDF
PubChem ID 44584784 Appearance Powder
Formula C26H30O13 M.Wt 550.5
Type of Compound Iridoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl (1S,4aS,5R,7aS)-7-(hydroxymethyl)-5-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
SMILES COC(=O)C1=COC(C2C1C(C=C2CO)OC(=O)C=CC3=CC=C(C=C3)O)OC4C(C(C(C(O4)CO)O)O)O
Standard InChIKey ABYPZHZWILXERF-BYMAQSFPSA-N
Standard InChI InChI=1S/C26H30O13/c1-35-24(34)15-11-36-25(39-26-23(33)22(32)21(31)17(10-28)38-26)19-13(9-27)8-16(20(15)19)37-18(30)7-4-12-2-5-14(29)6-3-12/h2-8,11,16-17,19-23,25-29,31-33H,9-10H2,1H3/b7-4+/t16-,17-,19-,20+,21-,22+,23-,25+,26+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of (E)-6-O-(p-coumaroyl)scandoside methyl ester

The fruits of Gardenia jasminoides

Biological Activity of (E)-6-O-(p-coumaroyl)scandoside methyl ester

Description(E)-6-O-(p-coumaroyl)scandoside methyl ester shows moderate anti-proliferation effect on PC3 human androgen-independent prostate cancer cells.
In vitro

Authentication of the anti-tumor herb Baihuasheshecao with bioactive marker compounds and molecular sequences.[Reference: WebLink]

Food Chemistry, 2010, 119(3):1239-1245.

Baihuasheshecao (Hedyotis diffusa), a Chinese herb for cancer treatment, is frequently adulterated by a related species Hedyotis corymbosa.
METHODS AND RESULTS:
DNA sequencing of the complete internal transcribed spacer region was applied to differentiate H. diffusa from H. corymbosa and other closely related species. The molecular data showed that four out of seven herb samples of Baihuasheshecao were adulterants. Chemical analyses by TLC and HPLC were used to authenticate H. diffusa and H. corymbosa. Two marker compounds were identified exclusively in H. diffusa: 6-O-(E)-p-coumaroyl scandoside methyl ester ((E)-6-O-(p-coumaroyl)scandoside methyl ester , compound 1) and 10(S)-hydroxypheophytin a (compound 2). Both compounds showed moderate anti-proliferation effect on PC3 human androgen-independent prostate cancer cells, while compound 2 also showed strong anti-proliferation effect on LNCaP human androgen-sensitive prostate cancer cells.
CONCLUSIONS:
Accordingly, these bioactive marker compounds could be applied to verify the authenticity and assess the quality of Baihuasheshecao.

Protocol of (E)-6-O-(p-coumaroyl)scandoside methyl ester

Kinase Assay

Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.[Pubmed: 30002289]

Int J Mol Sci. 2018 Jul; 19(7): 2027.

Hedyotis diffusa is a folk herb that is used for treating inflammation-related diseases in Asia. Previous studies have found that iridoids in H. diffusa play an important role in its anti-inflammatory activity.
METHODS AND RESULTS:
This study aimed to investigate the anti-inflammatory effect and potential mechanism of five iridoids (asperuloside (ASP), asperulosidic acid (ASPA), desacetyl asperulosidic acid (DAA), scandoside methyl ester (SME), and (E)-6-O-(p-coumaroyl)scandoside methyl ester (CSME)) that are presented in H. diffusa using lipopolysaccharide (LPS)—induced RAW 264.7 cells. ASP and ASPA significantly decreased the production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in parallel with the inhibition of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-α, and IL-6 mRNA expression in LPS-induced RAW 264.7 cells. ASP treatment suppressed the phosphorylation of the inhibitors of nuclear factor-kappaB alpha (IκB-α), p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK). The inhibitory effect of ASPA was similar to that of ASP, except for p38 phosphorylation.
CONCLUSIONS:
In summary, the anti-inflammatory effects of ASP and ASPA are related to the inhibition of inflammatory cytokines and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways, which provides scientific evidence for the potential application of H. diffusa.

Structure Identification
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 2;831(1-2):303-6.

Estimation of p-coumaric acid as metabolite of E-6-O-p-coumaroyl scandoside methyl ester in rat plasma by HPLC and its application to a pharmacokinetic study.[Pubmed: 16388996 ]


CONCLUSIONS:
A rapid and simple high-performance liquid chromatographic (HPLC) method has been developed for the determination of p-coumaric acid in rat plasma and applied to a pharmacokinetic study in rats after administration of a prodrug, (E)-6-O-(p-coumaroyl)scandoside methyl ester, isolated from Hedyotis diffusa (Willd.). Sample preparation involved protein precipitation with acetonitrile. The supernatant was then injected onto a Diamonsil C(18) column (250 mm x 4.6mm i.d., 5 microm). The mobile phase consisted of acetonitrile-water (21:79, v/v) with 1% glacial acetic acid. The UV detector was set at 310 nm. The lower limit of quantification of p-coumaric acid in rat plasma was 0.02 microg/mL. The calibration curves were linear over the concentration range 0.02-5 microg/mL with correlations greater than 0.999.
CONCLUSIONS:
The assay procedure was applied to the study of the metabolite pharmacokinetics of E-6-O-p-coumaroyl scandoside methyl ester in rat.

(E)-6-O-(p-coumaroyl)scandoside methyl ester Dilution Calculator

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(E)-6-O-(p-coumaroyl)scandoside methyl ester Molarity Calculator

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Preparing Stock Solutions of (E)-6-O-(p-coumaroyl)scandoside methyl ester

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8165 mL 9.0827 mL 18.1653 mL 36.3306 mL 45.4133 mL
5 mM 0.3633 mL 1.8165 mL 3.6331 mL 7.2661 mL 9.0827 mL
10 mM 0.1817 mL 0.9083 mL 1.8165 mL 3.6331 mL 4.5413 mL
50 mM 0.0363 mL 0.1817 mL 0.3633 mL 0.7266 mL 0.9083 mL
100 mM 0.0182 mL 0.0908 mL 0.1817 mL 0.3633 mL 0.4541 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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