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3-Hydroxy-3-acetonyloxindole

CAS# 33417-17-3

3-Hydroxy-3-acetonyloxindole

Catalog No. BCN4069----Order now to get a substantial discount!

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Quality Control of 3-Hydroxy-3-acetonyloxindole

Number of papers citing our products

Chemical structure

3-Hydroxy-3-acetonyloxindole

3D structure

Chemical Properties of 3-Hydroxy-3-acetonyloxindole

Cas No. 33417-17-3 SDF Download SDF
PubChem ID 36460 Appearance Powder
Formula C11H11NO3 M.Wt 205.2
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-hydroxy-3-(2-oxopropyl)-1H-indol-2-one
SMILES CC(=O)CC1(C2=CC=CC=C2NC1=O)O
Standard InChIKey CBMTTXBZZZABGG-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3-Hydroxy-3-acetonyloxindole

The herbs of Marsdenia tinctoria

Biological Activity of 3-Hydroxy-3-acetonyloxindole

DescriptionStandard reference
In vivo

Biological studies on indole derivatives. I. Synthesis and pharmacological studies of 2-oxo-3-indolyl derivatives.[Pubmed: 3604703]

Acta Physiol Pharmacol Latinoam. 1986;36(4):391-5.


METHODS AND RESULTS:
Two compounds, 3-Hydroxy-3-acetonyloxindole (I) and compound 3-acetonylidene-oxindole (II) were synthesized by a convenient method, and their pharmacological/toxicological effects were studied in rabbit.
CONCLUSIONS:
These compounds produced transitory effects on serum enzymes. The cholesterol mobilizing effect is more prominent with compound (I).

Protocol of 3-Hydroxy-3-acetonyloxindole

Structure Identification
J Pharm Sci. 1980 Oct;69(10):1235-7.

Synthesis of potential anticonvulsants: condensation of isatins with acetone and related ketones.[Pubmed: 6158569]


METHODS AND RESULTS:
Substituted isatins were condensed with acetone and other ketones to give analogs of 3-Hydroxy-3-acetonyloxindole. Some of these alcohols were dehydrated. Several compounds with anticonvulsant activity were obtained.

3-Hydroxy-3-acetonyloxindole Dilution Calculator

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3-Hydroxy-3-acetonyloxindole Molarity Calculator

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Preparing Stock Solutions of 3-Hydroxy-3-acetonyloxindole

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.8733 mL 24.3665 mL 48.7329 mL 97.4659 mL 121.8324 mL
5 mM 0.9747 mL 4.8733 mL 9.7466 mL 19.4932 mL 24.3665 mL
10 mM 0.4873 mL 2.4366 mL 4.8733 mL 9.7466 mL 12.1832 mL
50 mM 0.0975 mL 0.4873 mL 0.9747 mL 1.9493 mL 2.4366 mL
100 mM 0.0487 mL 0.2437 mL 0.4873 mL 0.9747 mL 1.2183 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 3-Hydroxy-3-acetonyloxindole

Biological studies on indole derivatives. I. Synthesis and pharmacological studies of 2-oxo-3-indolyl derivatives.[Pubmed:3604703]

Acta Physiol Pharmacol Latinoam. 1986;36(4):391-5.

Two compounds, 3-hydroxy-3-acetonyl-oxindole (I) and compound 3-acetonylidene-oxindole (II) were synthesized by a convenient method, and their pharmacological/toxicological effects were studied in rabbit. These compounds produced transitory effects on serum enzymes. The cholesterol mobilizing effect is more prominent with compound (I).

Synthesis of potential anticonvulsants: condensation of isatins with acetone and related ketones.[Pubmed:6158569]

J Pharm Sci. 1980 Oct;69(10):1235-7.

Substituted isatins were condensed with acetone and other ketones to give analogs of 3-Hydroxy-3-acetonyloxindole. Some of these alcohols were dehydrated. Several compounds with anticonvulsant activity were obtained.

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