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4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

CAS# 69768-97-4

4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

Catalog No. BCN4258----Order now to get a substantial discount!

Product Name & Size Price Stock
4-(3,4-Dimethoxyphenyl)-3-buten-1-ol: 5mg $615 In Stock
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Quality Control of 4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

Number of papers citing our products

Chemical structure

4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

3D structure

Chemical Properties of 4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

Cas No. 69768-97-4 SDF Download SDF
PubChem ID 6439118 Appearance Oil
Formula C12H16O3 M.Wt 208.3
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol
SMILES COC1=C(C=C(C=C1)C=CCCO)OC
Standard InChIKey HJXARZMWFOEQTO-HWKANZROSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

The herbs of Orophea yunnanensis

Biological Activity of 4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

Description(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypopigmentation-associated diseases.
TargetsERK | p38
In vitro

(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression.[Reference: WebLink]

PLOS ONE, 2015, 10(11):e0141988.


METHODS AND RESULTS:
We investigated the potential melanogenic effect of compounds from Zingiber cassumunar Roxb. Our data revealed that chloroform-soluble extract of Z. cassumunar enhanced melanin synthesis in B16F10 melanoma cells. Among the components of the chloroform extract, (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol (4-(3,4-Dimethoxyphenyl)-3-buten-1-ol, DMPB) increased melanogenesis in both B16F10 cells and human primary melanocytes. In B16F10 cells, DMPB enhanced the activation of ERK and p38, and the level of tyrosinase. Although the level of microphthalmia-associated transcription factor was unchanged in DMPB-treated B16F10 cells, DMPB increased levels and nuclear localization of upstream stimulating factor-1 (USF1). Consistently, DMPB-mediated melanin synthesis was diminished in USF1-knockdown cells. Furthermore, DMPB induced hyperpigmentation in brown guinea pigs in vivo.
CONCLUSIONS:
Together, these data suggest that DMPB may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypopigmentation-associated diseases.

4-(3,4-Dimethoxyphenyl)-3-buten-1-ol Dilution Calculator

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4-(3,4-Dimethoxyphenyl)-3-buten-1-ol Molarity Calculator

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Preparing Stock Solutions of 4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.8008 mL 24.0038 mL 48.0077 mL 96.0154 mL 120.0192 mL
5 mM 0.9602 mL 4.8008 mL 9.6015 mL 19.2031 mL 24.0038 mL
10 mM 0.4801 mL 2.4004 mL 4.8008 mL 9.6015 mL 12.0019 mL
50 mM 0.096 mL 0.4801 mL 0.9602 mL 1.9203 mL 2.4004 mL
100 mM 0.048 mL 0.24 mL 0.4801 mL 0.9602 mL 1.2002 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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