5-Methoxy-7-hydroxycoumarinCAS# 3067-10-5 |
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| Cas No. | 3067-10-5 | SDF | Download SDF |
| PubChem ID | 5487854 | Appearance | Powder |
| Formula | C10H8O4 | M.Wt | 192.2 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 7-hydroxy-5-methoxychromen-2-one | ||
| SMILES | COC1=C2C=CC(=O)OC2=CC(=C1)O | ||
| Standard InChIKey | IFIRYJJHHOCCHT-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The peel of Citrus medica L.
| Description | 1. 7-Hydroxy-5-methoxycoumarin, has been found to be a moderate inhibitor for aldehyde oxidase, a molybdo-flavoenzymes, it inhibits the release of superoxide anion more efficiently than hydrogen peroxide or substrate oxidation. |
5-Methoxy-7-hydroxycoumarin Dilution Calculator
5-Methoxy-7-hydroxycoumarin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.2029 mL | 26.0146 mL | 52.0291 mL | 104.0583 mL | 130.0728 mL |
| 5 mM | 1.0406 mL | 5.2029 mL | 10.4058 mL | 20.8117 mL | 26.0146 mL |
| 10 mM | 0.5203 mL | 2.6015 mL | 5.2029 mL | 10.4058 mL | 13.0073 mL |
| 50 mM | 0.1041 mL | 0.5203 mL | 1.0406 mL | 2.0812 mL | 2.6015 mL |
| 100 mM | 0.052 mL | 0.2601 mL | 0.5203 mL | 1.0406 mL | 1.3007 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Comparative Effects of Scopoletin and Menadione on Aldehyde Oxidase Activity of Guinea Pig Liver
J. Biol. Sci., 2005, 5(4):525-31.
Scopoletin, 7-hydroxy-5-methoxycoumarin, has been found to be a moderate inhibitor for aldehyde oxidase, a molybdo-flavoenzymes. It inhibits the release of superoxide anion more efficiently than hydrogen peroxide or substrate oxidation. Statistically, the inhibition of three-specific aldehyde oxidase substrates was significant (p<0.005) in the presence of 100 ?M Scopoletin. A progressive and non-competitive inhibition has been observed with inhibitor constant (Ki) value of 57.2?3.3 ?M using indole-3-aldehyde and oxygen as a substrate and electron acceptor, respectively. A specific site for interaction between Scopoletin and aldehyde oxidase has been proposed and its effect on the reactive oxygen species production has been discussed. The effect of Scopoletin on aldehyde oxidase activity has been compared with that of traditional and specific inhibitors, such as menadione.
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