AAL Toxin TC1

CAS# 176590-33-3

AAL Toxin TC1

Catalog No. BCN1736----Order now to get a substantial discount!

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Quality Control of AAL Toxin TC1

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Chemical structure

AAL Toxin TC1

3D structure

Chemical Properties of AAL Toxin TC1

Cas No. 176590-33-3 SDF Download SDF
PubChem ID 102004434 Appearance Powder
Formula C25H47NO8 M.Wt 489.65
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-[2-[(3R,4R,5S,7S,16S)-17-amino-4,16-dihydroxy-3,7-dimethylheptadecan-5-yl]oxy-2-oxoethyl]butanedioic acid
SMILES CCC(C)C(C(CC(C)CCCCCCCCC(CN)O)OC(=O)CC(CC(=O)O)C(=O)O)O
Standard InChIKey YZFDWMLFJPNPJS-YAUBIBOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of AAL Toxin TC1

The Alternaria alternata f. sp. lycopersici

Biological Activity of AAL Toxin TC1

Description1. AAL-toxin has a wide range of phytotoxicity, it has potential as a natural herbicide because several important weeds including jimsonweed, black nightshade, prickly sida and hemp sesbania are quite sensitive, while some crops such as cotton and maize are not affected.
TargetsAntifection

AAL Toxin TC1 Dilution Calculator

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AAL Toxin TC1 Molarity Calculator

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Preparing Stock Solutions of AAL Toxin TC1

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0423 mL 10.2114 mL 20.4228 mL 40.8455 mL 51.0569 mL
5 mM 0.4085 mL 2.0423 mL 4.0846 mL 8.1691 mL 10.2114 mL
10 mM 0.2042 mL 1.0211 mL 2.0423 mL 4.0846 mL 5.1057 mL
50 mM 0.0408 mL 0.2042 mL 0.4085 mL 0.8169 mL 1.0211 mL
100 mM 0.0204 mL 0.1021 mL 0.2042 mL 0.4085 mL 0.5106 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on AAL Toxin TC1

Fumonisin- and AAL-Toxin-Induced Disruption of Sphingolipid Metabolism with Accumulation of Free Sphingoid Bases.[Pubmed:12232389]

Plant Physiol. 1994 Nov;106(3):1085-1093.

Fumonisins (FB) and AAL-toxin(include AAL Toxin TC1) are sphingoid-like compounds produced by several species of fungi associated with plant diseases. In animal cells, both fumonisins produced by Fusarium moniliforme and AAL-toxin(include AAL Toxin TC1) produced by Alternaria alternata f. sp. lycopersici inhibit ceramide synthesis, an early biochemical event in the animal diseases associated with consumption of F. moniliforme-contaminated corn. In duckweed (Lemna pausicostata Heglem. 6746), tomato plants (Lycopersicon esculentum Mill), and tobacco callus (Nicotiana tabacum cv Wisconsin), pure FB1 or AAL-toxin(include AAL Toxin TC1) caused a marked elevation of phytosphingosine and sphinganine, sphingoid bases normally present in low concentrations. The relative increases were quite different in the three plant systems. Nonetheless, disruption of sphingolipid metabolism was clearly a common feature in plants exposed to FB1 or AAL-toxin(include AAL Toxin TC1). Resistant varieties of tomato (Asc/Asc) were much less sensitive to toxin-induced increases in free sphinganine. Because free sphingoid bases are precursors to plant "ceramides," their accumulation suggests that the primary biochemical lesion is inhibition of de novo ceramide synthesis and reacylation of free sphingoid bases. Thus, in plants the disease symptoms associated with A. alternata and F. moniliforme infection may be due to disruption of sphingolipid metabolism.

Arabidopsis AAL-toxin-resistant mutant atr1 shows enhanced tolerance to programmed cell death induced by reactive oxygen species.[Pubmed:18725200]

Biochem Biophys Res Commun. 2008 Oct 31;375(4):639-44.

The fungal AAL-toxin(include AAL Toxin TC1) triggers programmed cell death (PCD) through perturbations of sphingolipid metabolism in AAL-toxin-sensitive plants. While Arabidopsis is relatively insensitive to the toxin, the loh2 mutant exhibits increased susceptibility to AAL-toxin(include AAL Toxin TC1) due to the knockout of a gene involved in sphingolipid metabolism. Genetic screening of mutagenized loh2 seeds resulted in the isolation of AAL-toxin-resistant mutant atr1.Atr1 displays a wild type phenotype when grown on soil but it develops less biomass than loh2 on media supplemented with 2% and 3% sucrose. Atr1 was also more tolerant to the reactive oxygen species-generating herbicides aminotriazole (AT) and paraquat. Microarray analyses of atr1 and loh2 under AT-treatment conditions that trigger cell death in loh2 and no visible damage in atr1 revealed genes specifically regulated in atr1 or loh2. In addition, most of the genes strongly downregulated in both mutants were related to cell wall extension and cell growth, consistent with the apparent and similar AT-induced cessation of growth in both mutants. This indicates that two different pathways, a first controlling growth inhibition and a second triggering cell death, are associated with AT-induced oxidative stress.

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