Anonamine

CAS# 111566-66-6

Anonamine

Catalog No. BCN2139----Order now to get a substantial discount!

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Quality Control of Anonamine

Number of papers citing our products

Chemical structure

Anonamine

3D structure

Chemical Properties of Anonamine

Cas No. 111566-66-6 SDF Download SDF
PubChem ID 6441178 Appearance Powder
Formula C19H27NO7 M.Wt 381.42
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1CC(=CCO)C(=O)OC2CC[N+]3(C2(C(=CC3)COC(=O)C1(C)O)O)C
Standard InChIKey SFTHPGHXDNRVHD-FLRXXRQUSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Anonamine

The herbs of Senecio scandens

Biological Activity of Anonamine

DescriptionAnonamine is a natural product from Senecio scandens.
In vitro

Macrocyclic pyrrolizidine alkaloids from Senecio anonymus. Separation of a complex alkaloid extract using droplet counter-current chromatography.[Pubmed: 3210016]

J Nat Prod. 1988 Jul-Aug;51(4):690-702.


METHODS AND RESULTS:
Ten 12-membered macrocyclic pyrrolizidine alkaloids, all of them esters of the necines, retronecine or otonecine, have been isolated from Senecio anonymus. The separation, carried out by droplet counter-current chromatography, afforded senecionine [1], integerrimine [2], retrorsine [3], senkirkine [5], neosenkirkine [6], otosenine [10], hydroxysenkirkine [7], and a new alkaloid given the trivial name Anonamine [9]. Traces of usaramine [4] and another new alkaloid, hydroxyneosenkirkine [8], were detected by 1H nmr. In addition, the previously unreported 3a beta-hydroxy-4-ethoxy-2,6-perhydroindoledione [11] was isolated. X-ray structures were obtained for neosenkirkine [6], hydroxysenkirkine [7], Anonamine [9], and [11].
CONCLUSIONS:
1H-13C heteronuclear shift correlated nmr (HETCOR) provided unambiguous chemical shift assignments for 13C-nmr data. Antitumor activity was assayed using the A204-rhabdomyosarcoma cell line in soft agarose.

Protocol of Anonamine

Structure Identification
J Nat Prod. 1991 Sep-Oct;54(5):1425-6.

Acetylanonamine, a new secopyrrolizidine alkaloid from Senecio anonymus.[Pubmed: 1800641]

A new secopyrrolizidine alkaloid, acetylAnonamine, was isolated from Senecio anonymus.
METHODS AND RESULTS:
The structure was established by high resolution nmr (1H-1H COSY and 1H-13C HETCOR), ms, comparison of these spectral data with those of Anonamine, and synthesis of 1 from 2.

Anonamine Dilution Calculator

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Anonamine Molarity Calculator

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Preparing Stock Solutions of Anonamine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6218 mL 13.1089 mL 26.2178 mL 52.4356 mL 65.5445 mL
5 mM 0.5244 mL 2.6218 mL 5.2436 mL 10.4871 mL 13.1089 mL
10 mM 0.2622 mL 1.3109 mL 2.6218 mL 5.2436 mL 6.5545 mL
50 mM 0.0524 mL 0.2622 mL 0.5244 mL 1.0487 mL 1.3109 mL
100 mM 0.0262 mL 0.1311 mL 0.2622 mL 0.5244 mL 0.6554 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Anonamine

Acetylanonamine, a new secopyrrolizidine alkaloid from Senecio anonymus.[Pubmed:1800641]

J Nat Prod. 1991 Sep-Oct;54(5):1425-6.

A new secopyrrolizidine alkaloid, acetylAnonamine, was isolated from Senecio anonymus. The structure was established by high resolution nmr (1H-1H COSY and 1H-13C HETCOR), ms, comparison of these spectral data with those of Anonamine, and synthesis of 1 from 2.

Macrocyclic pyrrolizidine alkaloids from Senecio anonymus. Separation of a complex alkaloid extract using droplet counter-current chromatography.[Pubmed:3210016]

J Nat Prod. 1988 Jul-Aug;51(4):690-702.

Ten 12-membered macrocyclic pyrrolizidine alkaloids, all of them esters of the necines, retronecine or otonecine, have been isolated from Senecio anonymus. The separation, carried out by droplet counter-current chromatography, afforded senecionine [1], integerrimine [2], retrorsine [3], senkirkine [5], neosenkirkine [6], otosenine [10], hydroxysenkirkine [7], and a new alkaloid given the trivial name Anonamine [9]. Traces of usaramine [4] and another new alkaloid, hydroxyneosenkirkine [8], were detected by 1H nmr. In addition, the previously unreported 3a beta-hydroxy-4-ethoxy-2,6-perhydroindoledione [11] was isolated. X-ray structures were obtained for neosenkirkine [6], hydroxysenkirkine [7], Anonamine [9], and [11]. 1H-13C heteronuclear shift correlated nmr (HETCOR) provided unambiguous chemical shift assignments for 13C-nmr data. Antitumor activity was assayed using the A204-rhabdomyosarcoma cell line in soft agarose.

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