Home >> Research Area >>GPCR/G protein>>Cannabinoid Receptor>> Arachidonyl serotonin

Arachidonyl serotonin

Dual FAAH inhibitor/TRPV1 antagonist CAS# 187947-37-1

Arachidonyl serotonin

Catalog No. BCC7500----Order now to get a substantial discount!

Product Name & Size Price Stock
Arachidonyl serotonin: 5mg $69 In Stock
Arachidonyl serotonin: 10mg Please Inquire In Stock
Arachidonyl serotonin: 20mg Please Inquire Please Inquire
Arachidonyl serotonin: 50mg Please Inquire Please Inquire
Arachidonyl serotonin: 100mg Please Inquire Please Inquire
Arachidonyl serotonin: 200mg Please Inquire Please Inquire
Arachidonyl serotonin: 500mg Please Inquire Please Inquire
Arachidonyl serotonin: 1000mg Please Inquire Please Inquire
Related Products
  • UK-5099

    Catalog No.:BCC2021
    CAS No.:56396-35-1

Quality Control of Arachidonyl serotonin

Number of papers citing our products

Chemical structure

Arachidonyl serotonin

3D structure

Chemical Properties of Arachidonyl serotonin

Cas No. 187947-37-1 SDF Download SDF
PubChem ID 10027372 Appearance Powder
Formula C30H42N2O2 M.Wt 462.67
Type of Compound N/A Storage Desiccate at -20°C
Synonyms AA-5-HT
Solubility Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
Chemical Name (5Z,8Z,11Z,14Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14-tetraenamide
SMILES CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCC1=CNC2=C1C=C(C=C2)O
Standard InChIKey QJDNHGXNNRLIGA-DOFZRALJSA-N
Standard InChI InChI=1S/C30H42N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(34)31-23-22-26-25-32-29-21-20-27(33)24-28(26)29/h6-7,9-10,12-13,15-16,20-21,24-25,32-33H,2-5,8,11,14,17-19,22-23H2,1H3,(H,31,34)/b7-6-,10-9-,13-12-,16-15-
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Arachidonyl serotonin

DescriptionDual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.

Arachidonyl serotonin Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Arachidonyl serotonin Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Arachidonyl serotonin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1614 mL 10.8068 mL 21.6137 mL 43.2274 mL 54.0342 mL
5 mM 0.4323 mL 2.1614 mL 4.3227 mL 8.6455 mL 10.8068 mL
10 mM 0.2161 mL 1.0807 mL 2.1614 mL 4.3227 mL 5.4034 mL
50 mM 0.0432 mL 0.2161 mL 0.4323 mL 0.8645 mL 1.0807 mL
100 mM 0.0216 mL 0.1081 mL 0.2161 mL 0.4323 mL 0.5403 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Arachidonyl serotonin

Interactions of beta-lactoglobulin with serotonin and arachidonyl serotonin.[Pubmed:21732322]

Biopolymers. 2011 Dec;95(12):871-80.

beta-Lactoglobulin (beta-LG) is a lipocalin, which is the major whey protein of cow's milk and the milk of other mammals. However, it is absent from human milk. The biological function of beta-LG is not clear, but its potential role in carrying fatty acids through the digestive tract has been suggested. beta-LG has been found in complexes with lipids such as butyric and oleic acids and has a high affinity for a wide variety of compounds. Serotonin (5-hydroxytryptamine, 5-HT), an important compound found in animals and plants, has various functions, including the regulation of mood, appetite, sleep, muscle contraction, and some cognitive functions such as memory and learning. In this study, the interaction of serotonin and one of its derivatives, Arachidonyl serotonin (AA-5HT), with beta-LG was investigated using circular dichroism (CD) and fluorescence intensity measurements. These two ligands interact with beta-LG forming equimolar complexes. The binding constant for the serotonin/beta-LG interaction is between 10(5) and 10(6) M(-1) , whereas for the AA-5HT/beta-LG complex it is between 10(4) and 10(5) M(-1) as determined by measurements of either protein or ligand fluorescence. The observed binding affinities were higher in hydroethanolic media (25% EtOH). The interactions between serotonin/beta-LG and AA-5HT/beta-LG may compete with self-association (micellization) of both the ligand and the protein. According to far- and near-UV CD results, these ligands have no apparent influence on beta-LG secondary structure, however they partially destabilize its tertiary structure. Their binding by beta-LG may be one of the peripheral mechanisms of the regulation of the content of serotonin and its derivatives in the bowel of milk-fed animals.

Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.[Pubmed:17279090]

Br J Pharmacol. 2007 Mar;150(6):766-81.

BACKGROUND AND PURPOSE: N-arachidonoyl-serotonin (AA-5-HT) is an inhibitor of fatty acid amide hydrolase (FAAH)-catalysed hydrolysis of the endocannabinoid/ endovanilloid compound, anandamide (AEA). We investigated if AA-5-HT antagonizes the transient receptor potential vanilloid-1 (TRPV1) channel and, as FAAH and TRPV1 are targets for analgesic compounds, if it exerts analgesia in rodent models of hyperalgesia. EXPERIMENTAL APPROACH: AA-5-HT was tested in vitro, on HEK-293 cells overexpressing the human or the rat recombinant TRPV1 receptor, and in vivo, in rats and mice treated with formalin and in rats with chronic constriction injury of the sciatic nerve. The levels of the endocannabinoids, AEA and 2-arachidonoylglycerol, in supraspinal (periaqueductal grey, rostral ventromedial medulla), spinal or peripheral (skin) tissues were measured. KEY RESULTS: AA-5-HT behaved as an antagonist at both rat and human TRPV1 receptors (IC(50)=37-40 nM against 100 nM capsaicin). It exerted strong analgesic activity in all pain models used here. This activity was partly due to FAAH inhibition, elevation of AEA tissue levels and indirect activation of cannabinoid CB(1) receptors, as it was reversed by AM251, a CB(1) antagonist. AA-5-HT also appeared to act either via activation/desensitization of TRPV1, following elevation of AEA, or as a direct TRPV1 antagonist, as suggested by the fact that its effects were either reversed by capsazepine and 5'-iodo-resiniferatoxin, two TRPV1 antagonists, or mimicked by these compounds administered alone. CONCLUSIONS AND IMPLICATIONS: Possibly due to its dual activity as a FAAH inhibitor and TRPV1 antagonist, AA-5-HT was highly effective against both acute and chronic peripheral pain.

The endocannabinoid system and its therapeutic exploitation.[Pubmed:15340387]

Nat Rev Drug Discov. 2004 Sep;3(9):771-84.

The term 'endocannabinoid' - originally coined in the mid-1990s after the discovery of membrane receptors for the psychoactive principle in Cannabis, Delta9-tetrahydrocannabinol and their endogenous ligands - now indicates a whole signalling system that comprises cannabinoid receptors, endogenous ligands and enzymes for ligand biosynthesis and inactivation. This system seems to be involved in an ever-increasing number of pathological conditions. With novel products already being aimed at the pharmaceutical market little more than a decade since the discovery of cannabinoid receptors, the endocannabinoid system seems to hold even more promise for the future development of therapeutic drugs. We explore the conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come.

Keywords:

Arachidonyl serotonin,187947-37-1,AA-5-HT,Natural Products,Cannabinoid Receptor, buy Arachidonyl serotonin , Arachidonyl serotonin supplier , purchase Arachidonyl serotonin , Arachidonyl serotonin cost , Arachidonyl serotonin manufacturer , order Arachidonyl serotonin , high purity Arachidonyl serotonin

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: