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Aristolactam BIII

CAS# 53948-10-0

Aristolactam BIII

Catalog No. BCN5718----Order now to get a substantial discount!

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Quality Control of Aristolactam BIII

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Chemical structure

Aristolactam BIII

3D structure

Chemical Properties of Aristolactam BIII

Cas No. 53948-10-0 SDF Download SDF
PubChem ID 14526428 Appearance Yellow powder
Formula C18H15NO4 M.Wt 309.3
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES COC1=CC2=C3C4=C(C=C2C=C1)NC(=O)C4=CC(=C3OC)OC
Standard InChIKey OQKGOEOSXXHWFQ-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Aristolactam BIII

The herbs of Aristolochia debilis Sieb. et Zucc

Biological Activity of Aristolactam BIII

Description1. Aristolactam BIII has moderate antitumor activity in selected cell lines. 2. Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, HT-29 and A549 cell lines in vitro.
TargetsPAFR

Aristolactam BIII Dilution Calculator

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Aristolactam BIII Molarity Calculator

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Preparing Stock Solutions of Aristolactam BIII

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2331 mL 16.1655 mL 32.3311 mL 64.6621 mL 80.8277 mL
5 mM 0.6466 mL 3.2331 mL 6.4662 mL 12.9324 mL 16.1655 mL
10 mM 0.3233 mL 1.6166 mL 3.2331 mL 6.4662 mL 8.0828 mL
50 mM 0.0647 mL 0.3233 mL 0.6466 mL 1.2932 mL 1.6166 mL
100 mM 0.0323 mL 0.1617 mL 0.3233 mL 0.6466 mL 0.8083 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Aristolactam BIII

New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens.[Pubmed:15971125]

Planta Med. 2005 Jun;71(6):535-42.

Three new cyclobutanoid amides with trans-trans-trans configurations, piperarborenine C, piperarborenine D and piperarborenine E, and a new furanoid lignan, (+)-arborone, together with twelve known compounds, were isolated from the stems of Piper arborescens. The structures of these new compounds were determined by means of spectral analyses. Piperarborenine C, (+)-diayangambin, piplartine, piperolactam B, piperolactam C, Aristolactam BIII, goniothalactam, and methyl trans-3,4,5-trimethoxycinnamate possessed anti-platelet aggregation activity in vitro. Among them, piplartine showed the most potent anti-platelet aggregation activity induced by collagen and showed an IC50 value of 21.5 microM. Piperarborenines A - E, piperarborenine, aristololactam BIII and goniothalactam showed significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, HT-29 and A549 cell lines in vitro.

Synthesis of aristolactam analogues and evaluation of their antitumor activity.[Pubmed:19394218]

Bioorg Med Chem Lett. 2009 Jun 1;19(11):3036-40.

A series of natural aristolactams and their analogues have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B), Aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam showed moderate antitumor activities in selected cell lines. However, several synthetic aristolactam derivatives exhibited potent antitumor activities against a broad array of cancer cell lines with GI(50) values in the submicromolar range.

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