BMS-663068 TrisHIV-1 attachment inhibitor CAS# 864953-39-9 |
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Quality Control & MSDS
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| Cas No. | 864953-39-9 | SDF | Download SDF |
| PubChem ID | 46892186 | Appearance | Powder |
| Formula | C29H37N8O11P | M.Wt | 704.62 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Fostemsavir Tris; Fostemsavir tromethamine | ||
| Solubility | DMSO : 125 mg/mL (177.40 mM; Need ultrasonic) | ||
| Chemical Name | 2-amino-2-(hydroxymethyl)propane-1,3-diol;[3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrolo[2,3-c]pyridin-1-yl]methyl dihydrogen phosphate | ||
| SMILES | CC1=NN(C=N1)C2=NC=C(C3=C2N(C=C3C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5)COP(=O)(O)O)OC.C(C(CO)(CO)N)O | ||
| Standard InChIKey | RRGJSMBMTOKHTE-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C25H26N7O8P.C4H11NO3/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17;5-4(1-6,2-7)3-8/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38);6-8H,1-3,5H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | BMS-663068 Tris (Tromethamine) is the phosphonooxymethyl prodrug of BMS-626529. BMS-626529 is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.In Vivo:BMS-663068 has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent[1]. References: | |||||
BMS-663068 Tris Dilution Calculator
BMS-663068 Tris Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4192 mL | 7.096 mL | 14.192 mL | 28.3841 mL | 35.4801 mL |
| 5 mM | 0.2838 mL | 1.4192 mL | 2.8384 mL | 5.6768 mL | 7.096 mL |
| 10 mM | 0.1419 mL | 0.7096 mL | 1.4192 mL | 2.8384 mL | 3.548 mL |
| 50 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.5677 mL | 0.7096 mL |
| 100 mM | 0.0142 mL | 0.071 mL | 0.1419 mL | 0.2838 mL | 0.3548 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. BMS-663068 is a prodrug for BMS-626529 which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. Administration of BMS-663068 for 8 days with or without ritonavir resulted in substantial declines in plasma HIV-1 RNA levels and was generally well tolerated. Longer-term clinical trials of BMS-663068 as part of combination antiretroviral therapy are warranted.
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Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
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