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N-Methylcalycinine

CAS# 86537-66-8

N-Methylcalycinine

Catalog No. BCN4412----Order now to get a substantial discount!

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N-Methylcalycinine: 5mg $748 In Stock
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Quality Control of N-Methylcalycinine

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Chemical structure

N-Methylcalycinine

3D structure

Chemical Properties of N-Methylcalycinine

Cas No. 86537-66-8 SDF Download SDF
PubChem ID 14604497 Appearance Powder
Formula C19H19NO4 M.Wt 325.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CN1CCC2=CC3=C(C4=C2C1CC5=CC(=CC(=C54)O)OC)OCO3
Standard InChIKey SFOMHAXOBRLRFH-CYBMUJFWSA-N
Standard InChI InChI=1S/C19H19NO4/c1-20-4-3-10-7-15-19(24-9-23-15)18-16(10)13(20)6-11-5-12(22-2)8-14(21)17(11)18/h5,7-8,13,21H,3-4,6,9H2,1-2H3/t13-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of N-Methylcalycinine

The root of Stephania epigaea

Biological Activity of N-Methylcalycinine

Description1. N-Methylcalycinine exhibits potent AChE inhibitory activity.
TargetsAChR

N-Methylcalycinine Dilution Calculator

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N-Methylcalycinine Molarity Calculator

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Preparing Stock Solutions of N-Methylcalycinine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0731 mL 15.3657 mL 30.7314 mL 61.4628 mL 76.8285 mL
5 mM 0.6146 mL 3.0731 mL 6.1463 mL 12.2926 mL 15.3657 mL
10 mM 0.3073 mL 1.5366 mL 3.0731 mL 6.1463 mL 7.6829 mL
50 mM 0.0615 mL 0.3073 mL 0.6146 mL 1.2293 mL 1.5366 mL
100 mM 0.0307 mL 0.1537 mL 0.3073 mL 0.6146 mL 0.7683 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on N-Methylcalycinine

Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea.[Pubmed:26028544]

Fitoterapia. 2015 Jul;104:102-7.

An unusual proaporphine alkaloid bearing an isopropanenitrile group at isoquinoline nitrogen, named epiganine A (1) and a new aporphine alkaloid, epiganine B (2), together with eight known alkaloids, pronuciferine (3), dehydrodicentrine (4), romerine (5), romeline (6), N-Methylcalycinine (7), phanostenine (8), dicentrine (9), and N-methyllaurotetanine (10), were isolated from the roots of Stephania epigaea. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD) and comparing with experimental data. Compounds 2 and 4 showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 values of 4.36 and 2.98muM, respectively. Compounds 5-9 also exhibited potent AChE inhibitory activities.

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