Bisdethiobis(methylthio)gliotoxinCAS# 74149-38-5 |
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| Cas No. | 74149-38-5 | SDF | Download SDF |
| PubChem ID | 194564 | Appearance | Powder |
| Formula | C15H20N2O4S2 | M.Wt | 356.45 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3R,5aS,6S,10aR)-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylsulfanyl)-6,10-dihydro-5aH-pyrazino[1,2-a]indole-1,4-dione | ||
| SMILES | CN1C(=O)C2(CC3=CC=CC(C3N2C(=O)C1(CO)SC)O)SC | ||
| Standard InChIKey | OVBAGMZLGLXSBN-UOVKNHIHSA-N | ||
| Standard InChI | InChI=1S/C15H20N2O4S2/c1-16-12(20)14(22-2)7-9-5-4-6-10(19)11(9)17(14)13(21)15(16,8-18)23-3/h4-6,10-11,18-19H,7-8H2,1-3H3/t10-,11-,14+,15+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The fermentation products of Penicillium terlikowskii.
| Description | 1. Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist. |
| Targets | PAFR |
Bisdethiobis(methylthio)gliotoxin Dilution Calculator
Bisdethiobis(methylthio)gliotoxin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8054 mL | 14.0272 mL | 28.0544 mL | 56.1089 mL | 70.1361 mL |
| 5 mM | 0.5611 mL | 2.8054 mL | 5.6109 mL | 11.2218 mL | 14.0272 mL |
| 10 mM | 0.2805 mL | 1.4027 mL | 2.8054 mL | 5.6109 mL | 7.0136 mL |
| 50 mM | 0.0561 mL | 0.2805 mL | 0.5611 mL | 1.1222 mL | 1.4027 mL |
| 100 mM | 0.0281 mL | 0.1403 mL | 0.2805 mL | 0.5611 mL | 0.7014 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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A new diketopiperazine alkaloid from Aspergillus oryzae.[Pubmed:24116376]
Nat Prod Res. 2014;28(2):86-94.
Investigation of bioactive secondary metabolites from terrestrial Aspergillus oryzae sp. MMAO1 using M2 medium afforded a new diketopiperazine alkaloid, 7,9-dihydroxy-3-(1H-indol-3-ylmethyl)-8-methoxy-2,3,11,11a-tetrahydro-6H-pyrazino [1,2-b]isoquinoline-1,4-dione (1a), containing the unusual amino acid L-6,8-dihydroxy-7-methoxyphenylalanine. This was co-isolated with ditryptophenaline (2), cyclo-(Tryp,Tyr) (4), cyclo-(Pro,Val), alpha-cyclopiazonic acid (3), kojic acid and uridine. Re-cultivation of the fungal strain on Dox medium led to the production of bisdethio(bismethylthio)gliotoxin (5), pseurotin A (6) along with linoleic acid, alpha-cyclopiazonic acid (3) and kojic acid. The chemical structure of the new diketopiperazine alkaloid including the relative configuration was determined by 1D and 2D NMR spectroscopy and HR-ESI-MS spectrometry, and by comparison with the related literature. The new alkaloid (1a) showed no antimicrobial activity or cytotoxicity against brine shrimps.
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