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Carbamoylcholine chloride

Cholinergic receptor agonist CAS# 51-83-2

Carbamoylcholine chloride

Catalog No. BCC7492----Order now to get a substantial discount!

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Chemical structure

Carbamoylcholine chloride

3D structure

Chemical Properties of Carbamoylcholine chloride

Cas No. 51-83-2 SDF Download SDF
PubChem ID 5831 Appearance Powder
Formula C6H15ClN2O2 M.Wt 182.65
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Carbachol
Solubility H2O : ≥ 50 mg/mL (273.75 mM)
DMSO : 6.4 mg/mL (35.04 mM; Need ultrasonic and warming)
*"≥" means soluble, but saturation unknown.
Chemical Name 2-carbamoyloxyethyl(trimethyl)azanium;chloride
SMILES C[N+](C)(C)CCOC(=O)N.[Cl-]
Standard InChIKey AIXAANGOTKPUOY-UHFFFAOYSA-N
Standard InChI InChI=1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Carbamoylcholine chloride

DescriptionCholinergic receptor agonist that is resistant to the action of cholinesterases. Blocks apoptosis in cerebellar granule neurons.

Carbamoylcholine chloride Dilution Calculator

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Carbamoylcholine chloride Molarity Calculator

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Preparing Stock Solutions of Carbamoylcholine chloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.475 mL 27.3748 mL 54.7495 mL 109.499 mL 136.8738 mL
5 mM 1.095 mL 5.475 mL 10.9499 mL 21.8998 mL 27.3748 mL
10 mM 0.5475 mL 2.7375 mL 5.475 mL 10.9499 mL 13.6874 mL
50 mM 0.1095 mL 0.5475 mL 1.095 mL 2.19 mL 2.7375 mL
100 mM 0.0547 mL 0.2737 mL 0.5475 mL 1.095 mL 1.3687 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Carbamoylcholine chloride

Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling. IC50 value: 10 to 10,000 nM (Ki) Target: nAChR, mAChR Carbamoylcholine is an analog of acetylcholine that activates acetylcholine receptors (AChR). Carbamoylcholine is an agonist of both nicotinic (nAChR) and muscarinic (mAChR) receptors, with reported Ki values ranging from 10 to 10,000 nM for different receptors and different preparations.

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References on Carbamoylcholine chloride

Carbamoylcholine chloride induces a rapid increase in IL6 in the nasal cavity of C57BL/6 mice.[Pubmed:17803048]

Comp Med. 2007 Aug;57(4):349-54.

Mice are widely used as models to study the roles of chemokines and cytokines in immune and inflammatory responses. In our work to determine the basal levels of cytokines in saliva, nasal wash fluid (NWF), bronchoalveolar lavage fluid (BALF), and serum of mice, we found that injection of Carbamoylcholine chloride, used to stimulate saliva production, induced variations in the interleukin (IL) 6 levels of NWF and BALF supernatants. To characterize this response, C57BL/6 mice were given 10 microg Carbamoylcholine chloride intraperitoneally and euthanized at 0, 1, 3, 6, 12, 24, 48, 72, and 96 h after injection. IL6 was increased in NWF supernatants by 2 to 3 h, remained elevated for 24 h, and declined by 48 h after injection. To determine whether Carbamoylcholine chloride increased Th1 cytokine (IL2, IL12[p70], and interferon gamma), Th2 cytokine (IL4, IL5, and IL10), granulocyte-macrophage colony-stimulating factor (GM-CSF), or proinflammatory cytokine (IL1beta, tumor necrosis factor alpha, and IL6 in saliva and serum) levels, mice were given 10 microg Carbamoylcholine chloride and euthanized. In 47 mice, all cytokine levels in saliva supernatants, NWF supernatants, BALF supernatants, and serum were within normal reported levels (range, 1 to 364 pg/ml); in the serum of the remaining 3 mice, GM-CSF, IL1beta, and IL2 levels were increased. In summary, Carbamoylcholine chloride induces a rapid, elevated IL6 response in the nasal cavity and respiratory tract of mice but does not alter the levels of other Th1, Th2, or proinflammatory cytokines.

Description

Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.

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