Nicotinic Receptor - Neuroscience

Cat.No. Product Name Information

BCC7000 RJR 2429 dihydrochloride

BCC7264 α-Bungarotoxin

BCC6897 Methyllycaconitine citrate

BCC6176 SR 16584

BCC7468 Sazetidine A dihydrochloride

BCC7099 5-Iodo-A-85380 dihydrochloride

BCC6796 (±)-Anatoxin A fumarate

BCC7318 PNU 282987 PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).

BCC7793 RuBi-Nicotine

BCC6927 (-)-Lobeline hydrochloride Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.

BCC5935 Catestatin

BCC6615 1-Acetyl-4-methylpiperazine hydrochloride

BCC6750 (±)-Epibatidine (±)-Epibatidine is a nicotinic agonist. (±)-Epibatidine is a neuronal nAChR agonist.

BCC7301 DMAB-anabaseine dihydrochloride

BCC1901 RJR-2403 Rivanicline (RJR-2403; (E)-Metanicotine) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).

BCC7948 GTS 21 dihydrochloride GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.

BCC5974 α-Conotoxin ImI

BCC5979 α-Conotoxin EI

BCC5743 α-Conotoxin MII

BCC7827 AR-R 17779 hydrochloride

BCC6284 SIB 1553A hydrochloride SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders. SIB 1553A hydrochloride

BCC7975 SIB 1508Y maleate

BCC5746 UB 165 fumarate

BCC7705 3-Bromocytisine 3-Bromocytisine (3-Br-cytisine) is a potent nACh receptors agonist, with IC50s are 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7-nACh, respectively. 3-Bromocytisine (3-Br-cytisine) shows different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs with EC50s are 8 and 50 nM, respectively.

BCC7469 TC 2559 difumarate

BCC7102 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative

BCC5975 α-Conotoxin AuIB

BCC1902 RJR-2403 oxalate Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM).

BCC4156 Varenicline Hydrochloride Varenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist and full α7 nAChR agonist. Varenicline Hydrochloride is also a potent partial agonist of α6β2 nAChR in striatum of rats with a Ki value of 0.12 nM.

BCC4155 Varenicline Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment.

BCC7341 Dihydro-β-erythroidine hydrobromide Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active and competitive antagonist of neuronal nicotinic acetyicholine receptors (nAChRs). Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities.

BCC7700 S 24795 S 24795

BCC6641 Benzoquinonium dibromide Nicotinic antagonist

BCC7896 TQS TQS

BCC5972 PHA 543613 hydrochloride

BCC7569 (-)-Cotinine Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine, used as a biomarker for exposure to tobacco smoke.

BCC7535 NS 1738 NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4 μM in oocyte experiments). NS 1738

BCC7492 Carbamoylcholine chloride Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.

BCC7606 bPiDDB bPiDDB

BCC7574 PHA 568487

BCC7219 (+)-Anabasine hydrochloride

BCC1567 EVP-6124 hydrochloride Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).

BCC1566 EVP-6124 Encenicline (EVP-6124) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).

BCC7496 (+)-Tubocurarine chloride

BCC5976 α-Conotoxin PIA

BCC5978 α-Conotoxin PnIA

BCC5989 ACV 1 ACV 1

BCC6616 4-Acetyl-1,1-dimethylpiperazinium iodide

BCC7028 MG 624 MG 624

BCC7394 TC 1698 dihydrochloride

BCC7501 Mecamylamine hydrochloride Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier.

BCC7920 A 582941

BCC7360 TMPH hydrochloride

BCC6200 A 844606

BCC6182 SEN 12333

BCC7869 LY 2087101

BCC7788 CCMI CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction. CCMI

BCC1712 LX-1031 LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally. LX-1031

BCC6118 3-pyr-Cytisine

BCC7651 Desformylflustrabromine hydrochloride Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.

BCC6885 Chlorisondamine diiodide

Products for Nicotinic Receptor