Mecamylamine hydrochlorideNon-competitive nicotinic receptor antagonist CAS# 826-39-1 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 826-39-1 | SDF | Download SDF |
| PubChem ID | 13221 | Appearance | Powder |
| Formula | C11H22ClN | M.Wt | 203.75 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in water and to 75 mM in DMSO | ||
| Chemical Name | N,2,3,3-Tetramethylbicyclo[2.2.1]he | ||
| SMILES | [H+].[Cl-].CNC1(C)C2CCC(C2)C1(C)C | ||
| Standard InChIKey | PKVZBNCYEICAQP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice. |
Mecamylamine hydrochloride Dilution Calculator
Mecamylamine hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.908 mL | 24.5399 mL | 49.0798 mL | 98.1595 mL | 122.6994 mL |
| 5 mM | 0.9816 mL | 4.908 mL | 9.816 mL | 19.6319 mL | 24.5399 mL |
| 10 mM | 0.4908 mL | 2.454 mL | 4.908 mL | 9.816 mL | 12.2699 mL |
| 50 mM | 0.0982 mL | 0.4908 mL | 0.9816 mL | 1.9632 mL | 2.454 mL |
| 100 mM | 0.0491 mL | 0.2454 mL | 0.4908 mL | 0.9816 mL | 1.227 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Modeling study of mecamylamine block of muscle type acetylcholine receptors.[Pubmed:17938901]
Eur Biophys J. 2008 Apr;37(4):393-402.
The blocking action of mecamylamine on different types of nicotinic acetylcholine receptors (nAChRs) has been extensively studied and used as a tool to characterize the nAChRs from different synapses. However, mechanism of mecamylamine action was not fully explored for all types of nAChRs. In the present study, we provide brief description of the mecamylamine action on muscle nAChRs expressed at the frog neuromuscular junction. In this preparation mecamylamine block of nAChRs was accompanied by a use-dependent block relief induced by membrane depolarization combined with the activation of nAChRs by endogenous agonist acetylcholine (ACh). Further, three kinetic models of possible mecamylamine interaction with nAChRs were analyzed including simple open channel block, symmetrical trapping block and asymmetrical trapping block. This analysis suggested that mecamylamine action could be described on the basis of trapping mechanism, when the antagonist remained inside the channel even in the absence of bound agonist. Such receptors with trapped mecamylamine inside were predicted to have a closing rate constant about three times faster than resting one and a fast voltage-dependent unblocking rate constant. Specific experimental conditions and morphological organization of the neuromuscular synapses were considered to simulate time course of the mecamylamine block development. Thus, likewise for the neuronal nAChRs, the trapping mechanism determined the action of mecamylamine on synaptic neuromuscular currents evoked by the endogenous agonist acetylcholine (ACh), however specific morphological organization of the synaptic transmission delayed time development of the currents block.
