(+)-Tubocurarine chloride

Stability of tubocurarine chloride injection at ambient temperature and 4 deg C in polypropylene syringes.[Pubmed:23979307]

Int J Pharm Compd. 2002 Jul-Aug;6(4):308-10.

The stabililty of 3 mg/mL tubocurarine chloride injection in 3-mL polypropylene syringes stored at ambient temperature and at 4 deg C for up to 90 days was investigated. A high-performance liquid chromatographic stability-indicating assay was used to determine concentration levels of tubocurarine chloride injection 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the syringes. Benzyl alcohol, which was used as a preservative, did not interfere wiht the assay. At 25 deg C, the loss in potency was less than 10% after the syringes had been stored for 45 days; at 4 deg C, that loss was less than 1% after 90 days of storage. The pH of tubocurarine chloride injection did not change appreciably during the 90-day study period.

Characterization and evaluation of d-(+)-tubocurarine chloride as a chiral selector for capillary electrophoretic enantioseparations.[Pubmed:9529999]

Anal Chem. 1998 Mar 15;70(6):1059-65.

A new macrocyclic of the bis(benzylisoquinoline) alkaloid family, d-(+)-Tubocurarine chloride (DTC), has been evaluated as a chiral selector for the separation of optical isomers of organic carboxylates using capillary electrophoresis (CE). The pertinent physicochemical properties, such as absorption spectrum, isoionic point, and solution conformation, of DTC were determined. The effects of varying such experimental parameters as DTC concentration, pH, and methanol content in the running buffer were assessed. CE separation of the enantiomers of 18 different compounds was achieved using DTC as the chiral selector under optimized background electrolytic conditions.