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(+)-Tubocurarine chloride

Nicotinic receptor antagonist CAS# 57-94-3

(+)-Tubocurarine chloride

Catalog No. BCC7496----Order now to get a substantial discount!

Product Name & Size Price Stock
(+)-Tubocurarine chloride: 5mg $12 In Stock
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Quality Control of (+)-Tubocurarine chloride

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Chemical structure

(+)-Tubocurarine chloride

3D structure

Chemical Properties of (+)-Tubocurarine chloride

Cas No. 57-94-3 SDF Download SDF
PubChem ID 64645 Appearance Powder
Formula C37H42Cl2N2O6 M.Wt 681.65
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 25 mM in water and to 10 mM in DMSO
Chemical Name 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride
SMILES C[NH+]1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC.[Cl-].[Cl-]
Standard InChIKey GXFZCDMWGMFGFL-KKXMJGKMSA-N
Standard InChI InChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of (+)-Tubocurarine chloride

DescriptionCompetitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.

(+)-Tubocurarine chloride Dilution Calculator

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(+)-Tubocurarine chloride Molarity Calculator

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Preparing Stock Solutions of (+)-Tubocurarine chloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.467 mL 7.3351 mL 14.6703 mL 29.3406 mL 36.6757 mL
5 mM 0.2934 mL 1.467 mL 2.9341 mL 5.8681 mL 7.3351 mL
10 mM 0.1467 mL 0.7335 mL 1.467 mL 2.9341 mL 3.6676 mL
50 mM 0.0293 mL 0.1467 mL 0.2934 mL 0.5868 mL 0.7335 mL
100 mM 0.0147 mL 0.0734 mL 0.1467 mL 0.2934 mL 0.3668 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (+)-Tubocurarine chloride

Stability of tubocurarine chloride injection at ambient temperature and 4 deg C in polypropylene syringes.[Pubmed:23979307]

Int J Pharm Compd. 2002 Jul-Aug;6(4):308-10.

The stabililty of 3 mg/mL tubocurarine chloride injection in 3-mL polypropylene syringes stored at ambient temperature and at 4 deg C for up to 90 days was investigated. A high-performance liquid chromatographic stability-indicating assay was used to determine concentration levels of tubocurarine chloride injection 0, 1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the syringes. Benzyl alcohol, which was used as a preservative, did not interfere wiht the assay. At 25 deg C, the loss in potency was less than 10% after the syringes had been stored for 45 days; at 4 deg C, that loss was less than 1% after 90 days of storage. The pH of tubocurarine chloride injection did not change appreciably during the 90-day study period.

Characterization and evaluation of d-(+)-tubocurarine chloride as a chiral selector for capillary electrophoretic enantioseparations.[Pubmed:9529999]

Anal Chem. 1998 Mar 15;70(6):1059-65.

A new macrocyclic of the bis(benzylisoquinoline) alkaloid family, d-(+)-Tubocurarine chloride (DTC), has been evaluated as a chiral selector for the separation of optical isomers of organic carboxylates using capillary electrophoresis (CE). The pertinent physicochemical properties, such as absorption spectrum, isoionic point, and solution conformation, of DTC were determined. The effects of varying such experimental parameters as DTC concentration, pH, and methanol content in the running buffer were assessed. CE separation of the enantiomers of 18 different compounds was achieved using DTC as the chiral selector under optimized background electrolytic conditions.

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