Homatropine BromideMuscarinic AChR antagonist CAS# 51-56-9 |
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Quality Control & MSDS
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Chemical structure
3D structure
| Cas No. | 51-56-9 | SDF | Download SDF |
| PubChem ID | 6419941 | Appearance | White powder |
| Formula | C16H22BrNO3 | M.Wt | 356.25 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | Homatropine hydrobromide | ||
| Solubility | DMSO : 21.5 mg/mL (60.35 mM; Need ultrasonic and warming) | ||
| Chemical Name | [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate;hydrobromide | ||
| SMILES | CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br | ||
| Standard InChIKey | DWSGTFTVBLXELC-MOTQWOLNSA-N | ||
| Standard InChI | InChI=1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H/t12-,13+,14?,15?; | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Atropa belladonna L.
| Description | Homatropine Bromide is muscarinic AChR antagonist that is an anticholinergic medication.
Target: mAChR
Homatropine is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs [1]. Homatropine has similar affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses [2]. Homatropine [14C]methylbromide administrated rectal achieves higher and rapid peak plasma concentrations than by the other routes in rats whether HMB-14C is administered in a water-soluble suppository base or in aqueous solution, retained 28% of the 14C has been excreted in the urine while 56% remained in the large intestine after 12 hours. Unlabelled Homatropine methylbromide, given in rectal suppositories to anaesthetized rats, causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure [3]. References: | |||||
Homatropine Bromide Dilution Calculator
Homatropine Bromide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.807 mL | 14.0351 mL | 28.0702 mL | 56.1404 mL | 70.1754 mL |
| 5 mM | 0.5614 mL | 2.807 mL | 5.614 mL | 11.2281 mL | 14.0351 mL |
| 10 mM | 0.2807 mL | 1.4035 mL | 2.807 mL | 5.614 mL | 7.0175 mL |
| 50 mM | 0.0561 mL | 0.2807 mL | 0.5614 mL | 1.1228 mL | 1.4035 mL |
| 100 mM | 0.0281 mL | 0.1404 mL | 0.2807 mL | 0.5614 mL | 0.7018 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
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Homatropine Bromide is muscarinic AChR antagonist that is an anticholinergic medication.
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