AChR - Neuroscience

Cat.No. Product Name Information

BCC1324 A-867744 A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 μM.

BCN1946 Hyoscyamine L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine.

BCC4582 Trospium chloride Trospium Chloride is a competitive muscarinic cholinergic receptor antagonist.

BCC4563 Neostigmine Bromide Neostigmine Bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis.

BCC4148 Tarafenacin D-tartrate Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.

BCC1068 Rocuronium Bromide Rocuronium Bromide (ORG 9426 Bromide) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.

BCC5512 mAChR-IN-1 mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) antagonist with IC50 of 17 nM.

BCC6737 (±)-Vesamicol hydrochloride

BCC1900 Rivastigmine Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase IC50 value: 5.5 uM Target: AChE Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.

BCC4054 (R)-(+)-Tolterodine Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.

BCC3851 Rivastigmine Tartrate Rivastigmine tartrate, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase IC50 value: 5.5 uM Target: AChE Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease. Rivastigmine Tartrate

BCC2000 Tiotropium Bromide Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

BCC4585 Tiotropium Bromide hydrate Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.

BCC4146 Xanomeline oxalate Xanomeline oxalate (LY246708 oxalate) is a selective M1 muscarinic receptor agonist.

BCC1906 Rocuronium Rocuronium (Org-9426) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.

BCN6255 Pregnenolone Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication.

BCC4149 Oxybutynin chloride Oxybutynin chloride is an anticholinergic agent, which inhibits vascular Kv channels in a concentration-dependent manner, with an IC50 of 11.51 μM.

BCC4574 Tropicamide Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .

BCC5559 Nitenpyram Nitenpyram is a calss of neonicotinoid and an insect nicotinic acetylcholine receptor (nAChR) agonist with an IC50 of 14 nM. Nitenpyram is an oral fast-acting insecticide used to suppress sucking insects on companion animals.

BCC4577 Methscopolamine Methscopolamine (Pamine) is a muscarinic acetylcholine receptor blocker.

BCC4578 Pancuronium dibromide Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.

BCC6434 ML352 ML352

BCC5193 Solifenacin hydrochloride Solifenacin hydrochloride (YM905 hydrochloride) is a muscarinic receptor antagonist, with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.

BCN2869 Galantamine hydrobromide Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors.

BCC3795 Ipratropium Bromide Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.

BCC4573 Otilonium Bromide Octylonium bromide (SP63) is an antimuscarinic used as a spasmolytic agent.

BCN2913 Arecoline hydrobromide Arecoline hydrobromide (Arecoline bromide) is a muscarinic acetylcholine receptor agonist.

BCN2868 Galantamine Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

BCC5208 Flavoxate hydrochloride Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.

BCN2170 Varenicline tartrate Varenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.

BCC4147 Tarafenacin Tarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.

BCC4053 VU0152100 VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.

BCC4572 Orphenadrine Citrate Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

BCC4581 PNU-120596 PNU-120596 (NSC 216666 ) is a potent and selective positive allosteric α7 nAChR modulator with an EC50 of 0.2 μM.

BCC2498 Vecuronium Bromide Vecuronium bromide (ORG NC 45) is a nondepolarizing neuromuscular blocking agent of intermediate duration.

BCC4570 Homatropine Bromide Homatropine Bromide is muscarinic AChR antagonist that is an anticholinergic medication.

BCC4274 Biperiden Biperiden(KL 373) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.

BCC4568 Decamethonium Bromide Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

BCC4561 Hexamethonium Bromide Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

BCC3833 Oxybutynin Oxybutynin is an anticholinergic agent, which inhibits vascular Kv channels in a concentration-dependent manner, with an IC50 of 11.51 μM.

BCC4566 Bethanechol chloride Bethanechol Chloride (Carbamyl-β-methylcholine chloride) is a selective muscarinic receptor agonist without any effect on nicotinic receptors.

BCC3728 Atropine sulfate monohydrate Atropine sulfate monohydrate (Atropine sulfate hydrate) is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.

BCC4275 Glycopyrrolate Glycopyrrolate (Glycopyrronium bromide) is a muscarinic competitive antagonist used as an antispasmodic.

BCN2197 Acetylcholine chloride Acetylcholine chloride (ACh chloride) is a common neurotransmitter found in the central and peripheral nerve system.

BCC4564 Succinylcholine Chloride Dihydrate Succinylcholine Chloride Dihydrate is a nicotinic AChR agonist and also acts as a depolarizing neuromuscular blocker.

BCC3716 Acetylcysteine Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities.

BCC3767 Diphemanil Methylsulfate Diphemanil methylsulfate is a quaternary ammonium anticholinergic.

BCC5517 TBPB TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats. TBPB

BCC4576 Gallamine Triethiodide Gallamine Triethiodide is a synthetic nondepolarizing blocking drug.

BCC5054 Paroxetine HCl Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM.

BCC4571 Homatropine Methylbromide Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

BCC5564 LY2119620 LY2119620 is a high-affinity muscarinic M2/M4 receptor agonist.

Products for AChR