Home >> Research Area >>Neuroscience>>AChR>> Tarafenacin D-tartrate

Tarafenacin D-tartrate

CAS# 1159101-48-0

Tarafenacin D-tartrate

Catalog No. BCC4148----Order now to get a substantial discount!

Product Name & Size Price Stock
Tarafenacin D-tartrate: 5mg Please Inquire In Stock
Tarafenacin D-tartrate: 10mg Please Inquire In Stock
Tarafenacin D-tartrate: 20mg Please Inquire Please Inquire
Tarafenacin D-tartrate: 50mg Please Inquire Please Inquire
Tarafenacin D-tartrate: 100mg Please Inquire Please Inquire
Tarafenacin D-tartrate: 200mg Please Inquire Please Inquire
Tarafenacin D-tartrate: 500mg Please Inquire Please Inquire
Tarafenacin D-tartrate: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Tarafenacin D-tartrate

Number of papers citing our products

Chemical structure

Tarafenacin D-tartrate

3D structure

Chemical Properties of Tarafenacin D-tartrate

Cas No. 1159101-48-0 SDF Download SDF
PubChem ID 42622929 Appearance Powder
Formula C25H26F4N2O8 M.Wt 558.48
Type of Compound N/A Storage Desiccate at -20°C
Synonyms SVT-40776 D-tartrate
Solubility DMSO : ≥ 100 mg/mL (179.06 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name [(3R)-1-azabicyclo[2.2.2]octan-3-yl] N-(3-fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]carbamate;(2S,3S)-2,3-dihydroxybutanedioic acid
SMILES C1CN2CCC1C(C2)OC(=O)N(CC3=CC(=C(C(=C3)F)F)F)C4=CC(=CC=C4)F.C(C(C(=O)O)O)(C(=O)O)O
Standard InChIKey YJBKAMMKXVRSAI-CUCKRJOPSA-N
Standard InChI InChI=1S/C21H20F4N2O2.C4H6O6/c22-15-2-1-3-16(10-15)27(11-13-8-17(23)20(25)18(24)9-13)21(28)29-19-12-26-6-4-14(19)5-7-26;5-1(3(7)8)2(6)4(9)10/h1-3,8-10,14,19H,4-7,11-12H2;1-2,5-6H,(H,7,8)(H,9,10)/t19-;1-,2-/m00/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Tarafenacin D-tartrate

DescriptionTarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor. IC50 value: 0.19 nM (Ki) [1] Target: M3 muscarinic receptor in vitro: SVT-40776 is highly selective for M(3) over M(2) receptors (Ki = 0.19 nmol.L(-1) for M(3) receptor affinity). SVT-40776 was the most potent in inhibiting carbachol-induced bladder contractions of the anti-cholinergic agents tested, without affecting atrial contractions over the same range of concentrations. SVT-40776 exhibited the highest urinary versus cardiac selectivity (199-fold) [1]. SVT-40776 has a much higher binding affinity (K(d) = 0.4 nM) to M5 mAChR than that of solifenacin (K(d) = 31 nM) with the same reeptor. The calculated binding free energy change (-2.3 ± 0.3 kcal/mol) from solifenacin to SVT-40776 is in good agreement with the experimentally derived binding free energy change (-2.58 kcal/mol), suggesting that our modeled M5 mAChR structure and its complexes with the antagonists are reliable [2]. in vivo: In the guinea pig in vivo model, SVT-40776 inhibited 25% of spontaneous bladder contractions at a very low dose (6.97 microg.kg(-1) i.v), without affecting arterial blood pressure [1].

References:
[1]. Salcedo C, et al. In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. Br J Pharmacol. 2009 Mar;156(5):807-17. [2]. Huang X, et al. Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulation. J Phys Chem B. 2012 Jan 12;116(1):532-41.

Tarafenacin D-tartrate Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Tarafenacin D-tartrate Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Tarafenacin D-tartrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7906 mL 8.9529 mL 17.9057 mL 35.8115 mL 44.7644 mL
5 mM 0.3581 mL 1.7906 mL 3.5811 mL 7.1623 mL 8.9529 mL
10 mM 0.1791 mL 0.8953 mL 1.7906 mL 3.5811 mL 4.4764 mL
50 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.7162 mL 0.8953 mL
100 mM 0.0179 mL 0.0895 mL 0.1791 mL 0.3581 mL 0.4476 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Tarafenacin D-tartrate

Tarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.

Featured Products
New Products
 

Description

Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.

Keywords:

Tarafenacin D-tartrate,1159101-48-0,SVT-40776 D-tartrate,Natural Products,AChR, buy Tarafenacin D-tartrate , Tarafenacin D-tartrate supplier , purchase Tarafenacin D-tartrate , Tarafenacin D-tartrate cost , Tarafenacin D-tartrate manufacturer , order Tarafenacin D-tartrate , high purity Tarafenacin D-tartrate

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: