TC-I 2000TRPM8 blocker CAS# 1159996-20-9 |
- Nadifloxacin
Catalog No.:BCC4804
CAS No.:124858-35-1
- Calcipotriol monohydrate
Catalog No.:BCC1445
CAS No.:147657-22-5
- Halobetasol Propionate
Catalog No.:BCC4664
CAS No.:66852-54-8
- Dihydroartemisinin
Catalog No.:BCN6264
CAS No.:71939-50-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1159996-20-9 | SDF | Download SDF |
PubChem ID | 57326210 | Appearance | Powder |
Formula | C23H18F4N2O | M.Wt | 414.4 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble to 100 mM in DMSO and to 20 mM in ethanol | ||
Chemical Name | N-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxamide | ||
SMILES | C1CN(C(C2=CC=CC=C21)C3=CC=C(C=C3)C(F)(F)F)C(=O)NC4=CC=C(C=C4)F | ||
Standard InChIKey | ADCDUDFEGFKKQH-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C23H18F4N2O/c24-18-9-11-19(12-10-18)28-22(30)29-14-13-15-3-1-2-4-20(15)21(29)16-5-7-17(8-6-16)23(25,26)27/h1-12,21H,13-14H2,(H,28,30) | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM). |
TC-I 2000 Dilution Calculator
TC-I 2000 Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.4131 mL | 12.0656 mL | 24.1313 mL | 48.2625 mL | 60.3282 mL |
5 mM | 0.4826 mL | 2.4131 mL | 4.8263 mL | 9.6525 mL | 12.0656 mL |
10 mM | 0.2413 mL | 1.2066 mL | 2.4131 mL | 4.8263 mL | 6.0328 mL |
50 mM | 0.0483 mL | 0.2413 mL | 0.4826 mL | 0.9653 mL | 1.2066 mL |
100 mM | 0.0241 mL | 0.1207 mL | 0.2413 mL | 0.4826 mL | 0.6033 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Caulophine
Catalog No.:BCN7990
CAS No.:1159989-19-1
- Abiesadine N
Catalog No.:BCN6041
CAS No.:1159913-80-0
- CZC24832
Catalog No.:BCC1507
CAS No.:1159824-67-5
- Poricoic acid AE
Catalog No.:BCN7282
CAS No.:1159753-88-4
- Alstonic acid B
Catalog No.:BCN6040
CAS No.:1159579-45-9
- Alstonic acid A
Catalog No.:BCN6039
CAS No.:1159579-44-8
- Salvianolic acid B
Catalog No.:BCN6106
CAS No.:115939-25-8
- Tarafenacin D-tartrate
Catalog No.:BCC4148
CAS No.:1159101-48-0
- Angoroside C
Catalog No.:BCN4997
CAS No.:115909-22-3
- Tos-Arg-OH
Catalog No.:BCC2873
CAS No.:1159-15-5
- N1-Methoxymethyl picrinine
Catalog No.:BCN6038
CAS No.:1158845-78-3
- Aurora A Inhibitor I
Catalog No.:BCC2182
CAS No.:1158838-45-9
- Aldicarb
Catalog No.:BCC5475
CAS No.:116-06-3
- 4-Amino-3-hydroxy-1-naphthalenesulfonic acid
Catalog No.:BCC8680
CAS No.:116-63-2
- 1-Amino-4-hydroxyanthraquinone
Catalog No.:BCC8452
CAS No.:116-85-8
- VU 0238429
Catalog No.:BCC7729
CAS No.:1160247-92-6
- MLN4924 HCl salt
Catalog No.:BCC1773
CAS No.:1160295-21-5
- Pyr3
Catalog No.:BCC7771
CAS No.:1160514-60-2
- Piperolactam C
Catalog No.:BCN4818
CAS No.:116064-76-7
- Dehydromiltirone
Catalog No.:BCN5357
CAS No.:116064-77-8
- IDE 1
Catalog No.:BCC7841
CAS No.:1160927-48-9
- RETF-4NA
Catalog No.:BCC6073
CAS No.:1160928-63-1
- Z-Phe-OH
Catalog No.:BCC2756
CAS No.:1161-13-3
- Phenamil
Catalog No.:BCC7673
CAS No.:1161-94-0
Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.[Pubmed:22329507]
J Med Chem. 2012 Feb 23;55(4):1593-611.
The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in a subpopulation of sensory neurons that can be activated by a wide range of stimuli, including menthol, icilin, and cold temperatures (<25 degrees C). Antagonism of TRPM8 is currently under investigation as a new approach for the treatment of pain. As a result of our screening efforts, we identified tetrahydrothienopyridine 4 as an inhibitor of icilin-induced calcium influx in CHO cells expressing recombinant rat TRPM8. Exploration of the structure-activity relationships of 4 led to the identification of a potent and orally bioavailable TRPM8 antagonist, tetrahydroisoquinoline 87. Compound 87 demonstrated target coverage in vivo after oral administration in a rat pharmacodynamic model measuring the prevention of icilin-induced wet-dog shakes (WDS).