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Miglustat hydrochloride

Glycosyltransferase inhibitor; broad spectrum antiviral activity CAS# 210110-90-0

Miglustat hydrochloride

Catalog No. BCC5186----Order now to get a substantial discount!

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Chemical structure

Miglustat hydrochloride

3D structure

Chemical Properties of Miglustat hydrochloride

Cas No. 210110-90-0 SDF Download SDF
PubChem ID 6603107 Appearance Powder
Formula C10H22ClNO4 M.Wt 255.74
Type of Compound N/A Storage Desiccate at -20°C
Synonyms <em>N</em>-Butyldeoxynojirimycin hydrochloride, NB-DNJ
Solubility H2O : ≥ 34 mg/mL (132.95 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol;hydrochloride
SMILES CCCCN1CC(C(C(C1CO)O)O)O.Cl
Standard InChIKey QPAFAUYWVZMWPR-ZSOUGHPYSA-N
Standard InChI InChI=1S/C10H21NO4.ClH/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12;/h7-10,12-15H,2-6H2,1H3;1H/t7-,8+,9-,10-;/m1./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Miglustat hydrochloride

DescriptionOrally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

Miglustat hydrochloride Dilution Calculator

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Miglustat hydrochloride Molarity Calculator

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Preparing Stock Solutions of Miglustat hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9102 mL 19.5511 mL 39.1022 mL 78.2044 mL 97.7555 mL
5 mM 0.782 mL 3.9102 mL 7.8204 mL 15.6409 mL 19.5511 mL
10 mM 0.391 mL 1.9551 mL 3.9102 mL 7.8204 mL 9.7756 mL
50 mM 0.0782 mL 0.391 mL 0.782 mL 1.5641 mL 1.9551 mL
100 mM 0.0391 mL 0.1955 mL 0.391 mL 0.782 mL 0.9776 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Miglustat hydrochloride

Miglustat Hhydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

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References on Miglustat hydrochloride

N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.[Pubmed:8132559]

J Biol Chem. 1994 Mar 18;269(11):8362-5.

The imino sugar deoxynojirimycin and its alkylated derivatives are inhibitors of the N-linked oligosaccharide processing enzymes alpha-glucosidase I and II. These compounds are glucose analogues and have the potential to inhibit both glucosidases and glucosyltransferases. However, to date there has been no report of deoxynojirimycin or similar analogues inhibiting a mammalian glucosyltransferase. We have investigated the effects of deoxynojirimycin and its alkylated derivatives on the biosynthesis of glycolipids in HL-60 cells. We have found that the N-butyl and N-hexyl derivatives of deoxynojirimycin, but not deoxynojirimycin itself, are novel inhibitors of the glucosyltransferase-catalyzed biosynthesis of glucosylceramide. This results in the inhibition of biosynthesis of all glucosylceramide-based glycosphingolipids. We have investigated the ability of one of these compounds, N-butyldeoxynojirimycin, to offset glucosylceramide accumulation in an in vitro Gaucher's disease model. This compound prevents lysosomal glycolipid storage and offers a novel therapeutic approach for the management of this and other glycolipid storage disorders.

Description

Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).

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