GalanthaminoneCholinesterase(AChE) inhibitor CAS# 510-77-0 |
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Quality Control & MSDS
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| Cas No. | 510-77-0 | SDF | Download SDF |
| PubChem ID | 441596 | Appearance | Cryst. |
| Formula | C17H19NO3 | M.Wt | 285.3 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | (-)-Narwedine; Narwedin | ||
| Solubility | DMSO : 10 mg/mL (35.05 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||
| SMILES | CN1CCC23C=CC(=O)CC2OC4=C(C=CC(=C34)C1)OC | ||
| Standard InChIKey | QENVUHCAYXAROT-RHSMWYFYSA-N | ||
| Standard InChI | InChI=1S/C17H19NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,14H,7-10H2,1-2H3/t14-,17-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
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| Description | 1. Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. |
| Targets | AChR | IL Receptor |
Galanthaminone Dilution Calculator
Galanthaminone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5051 mL | 17.5254 mL | 35.0508 mL | 70.1016 mL | 87.6271 mL |
| 5 mM | 0.701 mL | 3.5051 mL | 7.0102 mL | 14.0203 mL | 17.5254 mL |
| 10 mM | 0.3505 mL | 1.7525 mL | 3.5051 mL | 7.0102 mL | 8.7627 mL |
| 50 mM | 0.0701 mL | 0.3505 mL | 0.701 mL | 1.402 mL | 1.7525 mL |
| 100 mM | 0.0351 mL | 0.1753 mL | 0.3505 mL | 0.701 mL | 0.8763 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Galantamine(Narwedin) is a competitive and reversible cholinesterase(AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
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Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition.[Pubmed:1914378]
Clin Pharmacol Ther. 1991 Oct;50(4):420-8.
Measurements were done to determine the plasma concentrations of galanthamine and two of its metabolites, as well as the corresponding inhibition of acetylcholinesterase activity in erythrocytes after applying 5 and 10 mg galanthamine hydrobromide as a constant-rate intravenous infusion for 30 minutes and single oral doses of 10 mg in eight healthy male volunteers. The data obtained revealed first-order pharmacokinetics, complete oral bioavailability, and a mean terminal half-life of 5.68 hours (95% confidence interval, 5.17 to 6.25 hours). Renal clearance accounted for only 25% of the total plasma clearance (CL = 0.34 L.kg-1.hr-1). Only negligible quantities of the putative metabolites, epigalanthamine and Galanthaminone, were detected in blood and urine. The inhibition of acetylcholinesterase activity was closely correlated with the pharmacokinetics of galanthamine, a median maximal value of 53% being achieved by applying 10 mg galanthamine intravenously. Analysis of in vitro and ex vivo concentration responses revealed no differences, indicating that no metabolites of galanthamine exert additional inhibition of acetylcholinesterase activity.
Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
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