Ceplignan

CAS# 185244-78-4

Ceplignan

Catalog No. BCN3626----Order now to get a substantial discount!

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Quality Control of Ceplignan

Number of papers citing our products

Chemical structure

Ceplignan

3D structure

Chemical Properties of Ceplignan

Cas No. 185244-78-4 SDF Download SDF
PubChem ID 102004693 Appearance Powder
Formula C18H18O7 M.Wt 346.3
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-carboxylic acid
SMILES COC1=CC(=CC2=C1OC(C2CO)C3=CC(=C(C=C3)O)OC)C(=O)O
Standard InChIKey MRHRLMTUTXWEQP-BLLLJJGKSA-N
Standard InChI InChI=1S/C18H18O7/c1-23-14-6-9(3-4-13(14)20)16-12(8-19)11-5-10(18(21)22)7-15(24-2)17(11)25-16/h3-7,12,16,19-20H,8H2,1-2H3,(H,21,22)/t12-,16+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Ceplignan

Description1. (2S,3R)-Ceplignan and (2R,3S)-Ceplignan significantly enhances SERT activity, can used in treatments of neuropsychiatric and digestive disorders.
Targets5-HT Receptor

Ceplignan Dilution Calculator

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Ceplignan Molarity Calculator

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Preparing Stock Solutions of Ceplignan

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8877 mL 14.4383 mL 28.8767 mL 57.7534 mL 72.1917 mL
5 mM 0.5775 mL 2.8877 mL 5.7753 mL 11.5507 mL 14.4383 mL
10 mM 0.2888 mL 1.4438 mL 2.8877 mL 5.7753 mL 7.2192 mL
50 mM 0.0578 mL 0.2888 mL 0.5775 mL 1.1551 mL 1.4438 mL
100 mM 0.0289 mL 0.1444 mL 0.2888 mL 0.5775 mL 0.7219 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ceplignan

A novel sesquiterpene and three new phenolic compounds from the rhizomes of Acorus tatarinowii Schott.[Pubmed:26296476]

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4214-8.

A novel sesquiterpene with an unprecedented epoxy lactone skeleton, named tatarinolactone, together with two new amides, a new biphenylpropanoid and two known lignans were isolated from the rhizomes of Acorus tatarinowii Schott. Their structures were identified as 6,7,8-trihydroxy-4alpha-isobutyl-4,7-dimethylhexahydro-6,8alpha-epoxychromen-2(3H )-one (1), (E)-methyl 4-[3-(4-hydroxy-3-methoxyphenyl)acrylamido]butanoate (2), (Z)-methyl 4-[3-(4-hydroxy-3-methoxyphenyl)acrylamido]butanoate enol isomer (3), (R)-4-hydroxy-3-[1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propan-2-yl]-5-methoxyben zoic acid (4), (2S,3R)-Ceplignan (5), and (2R,3S)-Ceplignan (6), respectively, based on extensive spectroscopic analysis and by comparison to the known compounds. To test their effects on serotonin transporters, a high content assay using hSERT-HEK293 cell line was adopted. Results indicated that compounds 1 and 4 significantly inhibited SERT activity, while compounds 2, 3, 5, and 6 significantly enhanced SERT activity, which partly explain the traditional uses of the rhizomes of Acorus tatarinowii Schott in treatments of neuropsychiatric and digestive disorders.

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