GBLD 345

benzodiazepine receptor agonist, potent CAS# 122479-08-7

GBLD 345

Catalog No. BCC6787----Order now to get a substantial discount!

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GBLD 345: 5mg $92 In Stock
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Chemical structure

GBLD 345

3D structure

Chemical Properties of GBLD 345

Cas No. 122479-08-7 SDF Download SDF
PubChem ID 4602899 Appearance Powder
Formula C21H21N5O2 M.Wt 375.43
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in ethanol and to 100 mM in DMSO
Chemical Name 2-(4-aminophenyl)-3-methoxy-N-[(3-methoxyphenyl)methyl]imidazo[1,2-b]pyridazin-6-amine
SMILES COC1=CC=CC(=C1)CNC2=NN3C(=NC(=C3OC)C4=CC=C(C=C4)N)C=C2
Standard InChIKey HQRHGSRWOHGIRI-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H21N5O2/c1-27-17-5-3-4-14(12-17)13-23-18-10-11-19-24-20(21(28-2)26(19)25-18)15-6-8-16(22)9-7-15/h3-12H,13,22H2,1-2H3,(H,23,25)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of GBLD 345

DescriptionA high affinity benzodiazepine agonist (IC50 against diazepam = 1 nM).

GBLD 345 Dilution Calculator

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GBLD 345 Molarity Calculator

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Preparing Stock Solutions of GBLD 345

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6636 mL 13.3181 mL 26.6361 mL 53.2722 mL 66.5903 mL
5 mM 0.5327 mL 2.6636 mL 5.3272 mL 10.6544 mL 13.3181 mL
10 mM 0.2664 mL 1.3318 mL 2.6636 mL 5.3272 mL 6.659 mL
50 mM 0.0533 mL 0.2664 mL 0.5327 mL 1.0654 mL 1.3318 mL
100 mM 0.0266 mL 0.1332 mL 0.2664 mL 0.5327 mL 0.6659 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on GBLD 345

GBLD 345 is a potent agonist of benzodiazepine receptor.

Benzodiazepine receptor is an allosteric modulatory site on GABAA receptor [1]. The GABAA receptor is a ligand-gated ion channel and activated by γ-aminobutyric acid (GABA). The GABAA receptor selectively permits Cl- through its pore and results in hyperpolarization of the neuron, which causes an inhibitory effect on neurotransmission.

GBLD 345 is a potent benzodiazepine receptor agonist with IC50 value of 1 nM against diazepam.

Reference:
[1].  Sieghart W. Pharmacology of benzodiazepine receptors: an update. J Psychiatry Neurosci, 1994, 19(1): 24-29.

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References on GBLD 345

A Retrospective Study on the Onset of Menopause after Chemotherapy: Analysis of Data Extracted from the Jean Perrin Comprehensive Cancer Center Database Concerning 345 Young Breast Cancer Patients Diagnosed between 1994 and 2012.[Pubmed:28171863]

Oncology. 2017;92(5):255-263.

OBJECTIVE: Young breast cancer (BC) patients receiving chemotherapy are at risk of chemotherapy-induced menopause (CIM). We sought to define the incidence rate of premature menopause after chemotherapy and to retrospectively investigate factors related to the onset of menopause. METHODS: We identified BC patients who had received chemotherapy at the Cancer Center (Centre Jean-Perrin). We selected premenopausal women aged between 18 and 50 years at the moment of diagnosis who received chemotherapy between 1994 and 2012. RESULTS: Of the 345 selected patients, the median age was 42 years (interquartile range: 38-46). CIM was defined as amenorrhea for at least 2 years following the end of chemotherapy. A total of 260 premenopausal women versus 85 menopausal women were included. Among the 85 menopausal women, only 46 were in the CIM group (13.3%). This rate increased in the group of women aged >43 years at diagnosis and with early hot flushes. CONCLUSION: CIM occurred in 13.3% of BC patients after chemotherapy. Age >43 years and early hot flushes were significantly associated with the risk of CIM. We suggest that the definition of CIM should be standardized in the literature: "amenorrhea of at least 2 years" seems a good cutoff, although 2 patients recovered their menstrual cycles beyond this limit.

Evaluation of matrix-assisted laser desorption/ionization time-of-fight mass spectrometry for identification of 345 clinical isolates of Aspergillus species from 11 Korean hospitals: comparison with molecular identification.[Pubmed:28336134]

Diagn Microbiol Infect Dis. 2017 Jan;87(1):28-31.

We evaluated the ability of the Filamentous Fungi Library 1.0 of the MALDI-TOF MS Biotyper system to identify 345 clinical Aspergillus isolates from 11 Korean hospitals. Compared with results of the internal transcribed spacer region sequencing, the frequencies of correct identification at the species-complex level were 94.5% and 98.8% with cutoff values of 2.0 and 1.7, respectively. Compared with results of beta-tubulin gene sequencing, the frequencies of correct identification at the species level were 96.0% (cutoff 2.0) and 100% (cutoff 1.7) for 303 Aspergillus isolates of five common, non-cryptic species, but only 4.8% (cutoff 1.7) and 0% (cutoff 2.0) for 42 Aspergillus isolates of six cryptic species (identifiable by beta-tubulin or calmodulin sequencing). These results show that the MALDI Biotyper using the Filamentous Fungi Library version 1.0 enables reliable identification of the majority of common clinical Aspergillus isolates, although the database should be expanded to facilitate identification of cryptic species.

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