HATU

CAS# 148893-10-1

HATU

Catalog No. BCC2813----Order now to get a substantial discount!

Product Name & Size Price Stock
HATU: 5mg $6 In Stock
HATU: 10mg Please Inquire In Stock
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Quality Control of HATU

Number of papers citing our products

Chemical structure

HATU

3D structure

Chemical Properties of HATU

Cas No. 148893-10-1 SDF Download SDF
PubChem ID 4641409 Appearance Powder
Formula C10H15F6N6OP M.Wt 380.2
Type of Compound N/A Storage Desiccate at -20°C
Solubility >16mg/mL in DMSO
Chemical Name [dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylidene]-dimethylazanium
SMILES CN(C)C(=[N+](C)C)ON1C2=C(C=CC=N2)N=N1
Standard InChIKey WXIONIWNXBAHRU-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H15N6O/c1-14(2)10(15(3)4)17-16-9-8(12-13-16)6-5-7-11-9/h5-7H,1-4H3/q+1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

HATU Dilution Calculator

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HATU Molarity Calculator

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Preparing Stock Solutions of HATU

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6302 mL 13.151 mL 26.3019 mL 52.6039 mL 65.7549 mL
5 mM 0.526 mL 2.6302 mL 5.2604 mL 10.5208 mL 13.151 mL
10 mM 0.263 mL 1.3151 mL 2.6302 mL 5.2604 mL 6.5755 mL
50 mM 0.0526 mL 0.263 mL 0.526 mL 1.0521 mL 1.3151 mL
100 mM 0.0263 mL 0.1315 mL 0.263 mL 0.526 mL 0.6575 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

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Yale University

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Universidade da Beira Interior

The Institute of Cancer Research

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Jilin University
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Universite de Paris
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The University of Tokyo
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Korea University
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Background on HATU

A peptide coupling reagent.

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References on HATU

Mineral resources prospecting by synthetic application of TM/ETM+, Quickbird and Hyperion data in the Hatu area, West Junggar, Xinjiang, China.[Pubmed:26911195]

Sci Rep. 2016 Feb 25;6:21851.

The HATU area, West Junggar, Xinjiang, China, is situated at a potential gold-copper mineralization zone in association with quartz veins and small granitic intrusions. In order to identify the alteration zones and mineralization occurrences in this area, the Landsat Thematic Mapper (TM) and Enhanced Thematic Mapper (ETM+), Quickbird, Hyperion data and laboratory measured spectra were combined in identifying structures, alteration zones, quartz veins and small intrusions. The hue-saturation-intensity (HSI) color model transformation was applied to transform principal component analysis (PCA) combinations from R (Red), G (Green) and B (Blue) to HSI space to enhance faults. To wipe out the interference of the noise, a method, integrating Crosta technique and anomaly-overlaying selection, was proposed and implemented. Both Jet Propulsion Laboratory Spectral Library spectra and laboratory-measured spectra, combining with matched filtering method, were used to process Hyperion data. In addition, high-resolution Quickbird data were used for unraveling the quartz veins and small intrusions along the alteration zones. The Baobei fault and a SW-NE-oriented alteration zone were identified for the first time. This study eventually led to the discovery of four weak gold-copper mineralized locations through ground inspection and brought new geological knowledge of the region's metallogeny.

Evaluation of combined use of Oxyma and HATU in aggregating peptide sequences.[Pubmed:28139012]

J Pept Sci. 2017 Apr;23(4):272-281.

Polypeptides are finding increasing applications as therapeutics because of their specificity that often translates into excellent safety, tolerability, and efficacy profiles in humans. New synthetic methodologies for their preparation are thereby continuously sought to reduce the costs associated to chain assembly and purification. Although solid-phase peptide synthesis has become one of the most advanced synthetic procedures at both laboratory and industrial scale, the process is often complicated by aggregation phenomena originating from the combined occurrence of intermolecular and intramolecular hydrogen bonding, hydrophobic interactions, or other effects. Altogether, these effects cause accumulation of many side products and synthetic mixtures extremely hard to separate and purify, strongly affecting the costs of the final material. In the attempt to optimize the coupling steps of some well-known aggregating or otherwise difficult to obtain peptides, we have comparatively investigated the use of Oxyma/DIC and HATU/Sym-collidine as second coupling reagents in double coupling settings for the preparation of some model peptides. Comparative analytical data obtained on the unpurified products with the two different protocols clearly show that the use of Oxyma/DIC largely improves the content of the target molecules in the final crude materials, making the synthesis more convenient and cost-effective. Copyright (c) 2017 European Peptide Society and John Wiley & Sons, Ltd.

Peptide bond-forming reagents HOAt and HATU are not mutagenic in the bacterial reverse mutation test.[Pubmed:26840011]

Environ Mol Mutagen. 2016 Apr;57(3):236-40.

The peptide bond-forming reagents 1-hydroxy-7-azabenzotriazole (HOAt, CAS 39968-33-7) and O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU, CAS 148893-10-1) either have structural alerts, unclassified features or are considered out of domain when evaluated for potential mutagenicity with in silico programs DEREK and CaseUltra. Since they are commonly used reagents in pharmaceutical drug syntheses, they may become drug substance or drug product impurities and would need to be either controlled to appropriately safe levels or tested for mutagenicity. Both reagents were tested in the bacterial reverse mutation (Ames) test at Covance, under GLP conditions, following the OECD test guideline and ICH S2(R1) recommendations and found to be negative. Our data show that HOAt and HATU-common pharmaceutical synthesis reagents-are not mutagenic, and can be treated as ordinary drug impurities.

Rapid HATU-mediated solution phase siRNA conjugation.[Pubmed:21744777]

Bioconjug Chem. 2011 Aug 17;22(8):1723-8.

Conditions for facile solution-phase amide conjugation of amine-modified siRNA with a diverse set of carboxylic acid partners using the coupling reagent HATU are described. These conditions eliminate the need for isolated activated esters and allow for rapid access to conjugates with a wide range of lipophilicity and functionality in good yield.

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