Lacinilene C

CAS# 41653-72-9

Lacinilene C

Catalog No. BCN5474----Order now to get a substantial discount!

Product Name & Size Price Stock
Lacinilene C: 5mg $799 In Stock
Lacinilene C: 10mg Please Inquire In Stock
Lacinilene C: 20mg Please Inquire Please Inquire
Lacinilene C: 50mg Please Inquire Please Inquire
Lacinilene C: 100mg Please Inquire Please Inquire
Lacinilene C: 200mg Please Inquire Please Inquire
Lacinilene C: 500mg Please Inquire Please Inquire
Lacinilene C: 1000mg Please Inquire Please Inquire

Quality Control of Lacinilene C

Number of papers citing our products

Chemical structure

Lacinilene C

3D structure

Chemical Properties of Lacinilene C

Cas No. 41653-72-9 SDF Download SDF
PubChem ID 170551 Appearance Yellow powder
Formula C15H18O3 M.Wt 246.3
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R)-1,7-dihydroxy-1,6-dimethyl-4-propan-2-ylnaphthalen-2-one
SMILES CC1=C(C=C2C(=C1)C(=CC(=O)C2(C)O)C(C)C)O
Standard InChIKey JLCJSBOHWRDWQW-OAHLLOKOSA-N
Standard InChI InChI=1S/C15H18O3/c1-8(2)10-6-14(17)15(4,18)12-7-13(16)9(3)5-11(10)12/h5-8,16,18H,1-4H3/t15-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lacinilene C

The barks of Ulmus parvifolia Jacq.

Biological Activity of Lacinilene C

Description1. Lacinilene C methyl ether elicits contraction of TSM by enhancing the movement of calcium through potential-dependent channels of smooth muscle cell membranes. 2. Lacinilene C, lacinilene C 7-methyl ether, scopoletin, 2-hydroxy-7-methoxycadalene and 2,7-dihydroxycadalene are 5 induced phytoalexins in cotton leaves.
TargetsP450 (e.g. CYP17) | 5-HT Receptor | Histamine Receptor

Lacinilene C Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Lacinilene C Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Lacinilene C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.0601 mL 20.3004 mL 40.6009 mL 81.2018 mL 101.5022 mL
5 mM 0.812 mL 4.0601 mL 8.1202 mL 16.2404 mL 20.3004 mL
10 mM 0.406 mL 2.03 mL 4.0601 mL 8.1202 mL 10.1502 mL
50 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
100 mM 0.0406 mL 0.203 mL 0.406 mL 0.812 mL 1.015 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Lacinilene C

RNAi construct of a cytochrome P450 gene CYP82D109 blocks an early step in the biosynthesis of hemigossypolone and gossypol in transgenic cotton plants.[Pubmed:25794893]

Phytochemistry. 2015 Jul;115:59-69.

Naturally occurring terpenoid aldehydes from cotton, such as hemigossypol, gossypol, hemigossypolone, and the heliocides, are important components of disease and herbivory resistance in cotton. These terpenoids are predominantly found in the glands. Differential screening identified a cytochrome P450 cDNA clone (CYP82D109) from a Gossypium hirsutum cultivar that hybridized to mRNA from glanded cotton but not glandless cotton. Both the D genome cotton Gossypium raimondii and A genome cotton Gossypium arboreum possessed three additional paralogs of the gene. G. hirsutum was transformed with a RNAi construct specific to this gene family and eight transgenic plants were generated stemming from at least five independent transformation events. HPLC analysis showed that RNAi plants, when compared to wild-type Coker 312 (WT) plants, had a 90% reduction in hemigossypolone and heliocides levels, and a 70% reduction in gossypol levels in the terminal leaves, respectively. Analysis of volatile terpenes by GC-MS established presence of an additional terpene (MW: 218) from the RNAi leaf extracts. The (1)H and (13)C NMR spectroscopic analyses showed this compound was delta-cadinen-2-one. Double bond rearrangement of this compound gives 7-hydroxycalamenene, a Lacinilene C pathway intermediate. delta-Cadinen-2-one could be derived from delta-cadinene via a yet to be identified intermediate, delta-cadinen-2-ol. The RNAi construct of CYP82D109 blocks the synthesis of desoxyhemigossypol and increases the induction of Lacinilene C pathway, showing that these pathways are interconnected. Lacinilene C precursors are not constitutively expressed in cotton leaves, and blocking the gossypol pathway by the RNAi construct resulted in a greater induction of the Lacinilene C pathway compounds when challenged by pathogens.

Lacinilene C methyl ether (LCME) constricts tracheal smooth muscle.[Pubmed:3338430]

Environ Res. 1988 Feb;45(1):118-26.

Lacinilene C methyl ether (LCME) is a constituent of the cotton plant and has been implicated as a causative agent of byssinosis. The effect of synthetic LCME on the behavior of isolated strips of canine tracheal smooth muscle (TSM) was examined in tissue bath experiments. LCME (0.64-6.6 x 10(-4) M) caused slowly developing but strong and sustained contractions of TSM strips. Blockade of acetycholine, 5-hydroxytryptamine (5-HT), and histamine H1 receptors with atropine, methysergide, and pyrilamine, respectively, had no effect on constrictions induced by LCME. In contrast, the calcium channel antagonist, verapamil, significantly reduced the response to LCME. Moreover, addition of the beta receptor agonist, isoproterenol, at the peak of LCME-induced contractions relaxed tissues in a concentration-dependent manner. We conclude that LCME elicits contraction of TSM by enhancing the movement of calcium through potential-dependent channels of smooth muscle cell membranes. This mechanism of action does not require activation of specific membrane receptors for acetylcholine, 5-HT, and histamine.

Keywords:

Lacinilene C,41653-72-9,Natural Products, buy Lacinilene C , Lacinilene C supplier , purchase Lacinilene C , Lacinilene C cost , Lacinilene C manufacturer , order Lacinilene C , high purity Lacinilene C

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: