LindereneCAS# 26146-27-0 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 26146-27-0 | SDF | Download SDF |
| PubChem ID | 497203 | Appearance | Powder |
| Formula | C15H18O2 | M.Wt | 230.3 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1=COC2=C1C(C3C(=C)C4CC4C3(C2)C)O | ||
| Standard InChIKey | XRDJYSVGPBJZSG-PSDLAXTLSA-N | ||
| Standard InChI | InChI=1S/C15H18O2/c1-7-6-17-11-5-15(3)10-4-9(10)8(2)13(15)14(16)12(7)11/h6,9-10,13-14,16H,2,4-5H2,1,3H3/t9-,10-,13-,14+,15+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Linderene, linderalactone and isolinderalactone inhibit the enzymes from both origins to the same extent. |
| Kinase Assay | Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill.[Pubmed: 12186408]Biol Pharm Bull. 2002 Aug;25(8):1049-52.We studied the PEP inhibitory constituents of the roots of Lindera strychnifolia F. VILL and isolated two known tannins, epicatechin (1) and aesculitannin B (2), and four known sesquiterpenes, Linderene (3), Linderene acetate (4), linderalactone (5) and isolinderalactone (6) as inhibitors.
|
Linderene Dilution Calculator
Linderene Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.3422 mL | 21.7108 mL | 43.4216 mL | 86.8432 mL | 108.5541 mL |
| 5 mM | 0.8684 mL | 4.3422 mL | 8.6843 mL | 17.3686 mL | 21.7108 mL |
| 10 mM | 0.4342 mL | 2.1711 mL | 4.3422 mL | 8.6843 mL | 10.8554 mL |
| 50 mM | 0.0868 mL | 0.4342 mL | 0.8684 mL | 1.7369 mL | 2.1711 mL |
| 100 mM | 0.0434 mL | 0.2171 mL | 0.4342 mL | 0.8684 mL | 1.0855 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- MB05032
Catalog No.:BCC1731
CAS No.:261365-11-1
- Antiarol rutinoside
Catalog No.:BCN5137
CAS No.:261351-23-9
- Frentizole
Catalog No.:BCC4035
CAS No.:26130-02-9
- 4-O-Feruloylquinic acid
Catalog No.:BCN3352
CAS No.:2613-86-7
- Madurensine
Catalog No.:BCN2092
CAS No.:26126-78-3
- Picrasin B
Catalog No.:BCN5136
CAS No.:26121-56-2
- Rhodojaponin II
Catalog No.:BCN2810
CAS No.:26116-89-2
- Cyanidin-3,5-O-diglucoside chloride
Catalog No.:BCN3116
CAS No.:2611-67-8
- Chicago Sky Blue 6B
Catalog No.:BCC6816
CAS No.:2610-05-1
- Reneilmol
Catalog No.:BCN5135
CAS No.:260968-11-4
- Otilonium Bromide
Catalog No.:BCC4573
CAS No.:26095-59-0
- AMC
Catalog No.:BCC2837
CAS No.:26093-31-2
- Linderene acetate
Catalog No.:BCN8042
CAS No.:26146-28-1
- 3,5-Dihydroxybenzaldehyde
Catalog No.:BCN2257
CAS No.:26153-38-8
- Naproxen Sodium
Catalog No.:BCC6490
CAS No.:26159-34-2
- CGS 35066
Catalog No.:BCC5916
CAS No.:261619-50-5
- Denudatine
Catalog No.:BCN5406
CAS No.:26166-37-0
- Beesioside Q
Catalog No.:BCC8301
CAS No.:261767-91-3
- 3,19-Dihydroxy-6,23-dioxo-12-ursen-28-oic acid
Catalog No.:BCN1471
CAS No.:261768-88-1
- 6-Methyl-8-prenylnaringenin
Catalog No.:BCN6860
CAS No.:261776-60-7
- 6-Prenylsakuranetin
Catalog No.:BCN7883
CAS No.:261776-61-8
- Foliamenthoic acid
Catalog No.:BCN5138
CAS No.:26187-80-4
- SB269970 HCl
Catalog No.:BCC5056
CAS No.:261901-57-9
- Isotaxiresinol
Catalog No.:BCN4660
CAS No.:26194-57-0
Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill.[Pubmed:12186408]
Biol Pharm Bull. 2002 Aug;25(8):1049-52.
Prolyl endopeptidase (PEP, EC 3.4.21.26) has been proposed to play a role in degradation of proline-containing neuropeptides involved in the processes of learning and memory, e.g., vasopressin, substance P, and thyrotropin-releasing hormone (TRH). In the course of our search for bioactive constituents in medicinal plants, we studied the PEP inhibitory constituents of the roots of Lindera strychnifolia F. VILL and isolated two known tannins, epicatechin (1) and aesculitannin B (2), and four known sesquiterpenes, Linderene (3), Linderene acetate (4), linderalactone (5) and isolinderalactone (6) as inhibitors. On the inhibitory activities of six compounds against PEP from Flavobacterium meningosepticum and that from rat brain supernatant, compounds 1, 2 and 4 inhibited the enzyme from Flavobacterium more strongly than that from rat brain supernatant. However, compounds 3, 5 and 6 inhibited the enzymes from both origins to the same extent and furthermore, compound 6 was the strongest natural inhibitor against PEP from rat brain supernatant. The kinetic study of these inhibitors indicated that compounds 1, 2 are noncompetitive inhibitors and compounds 3-6 are competitive inhibitors. This is the first example of non-phenolic constituents showing significant competitive inhibitory activity being isolated from natural medicines.
