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Methyl tanshinonate

CAS# 18887-19-9

Methyl tanshinonate

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Methyl tanshinonate: 5mg $725 In Stock
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Quality Control of Methyl tanshinonate

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Chemical structure

Methyl tanshinonate

3D structure

Chemical Properties of Methyl tanshinonate

Cas No. 18887-19-9 SDF Download SDF
PubChem ID 624381 Appearance Red powder
Formula C20H18O5 M.Wt 338.35
Type of Compound Diterpenoids Storage Desiccate at -20°C
Synonyms Methyltanshinonate;Methuyl Tanshinonate
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl 1,6-dimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-6-carboxylate
SMILES CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C(=O)OC
Standard InChIKey YFDKIHAZVQFLRC-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H18O5/c1-10-9-25-18-12-6-7-13-11(15(12)17(22)16(21)14(10)18)5-4-8-20(13,2)19(23)24-3/h6-7,9H,4-5,8H2,1-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Methyl tanshinonate

The roots of Salvia miltiorrhiza

Biological Activity of Methyl tanshinonate

Description1. Methyl tanshinonate (Methyltanshinonate) has antioxidant activity.
2. Methyl tanshinonate (Methyltanshinonate) can treat psoriasis.
3. Methyl tanshinonate (Methyltanshinonate) has antiatherosclerotic activity.
TargetsAntifection

Methyl tanshinonate Dilution Calculator

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Methyl tanshinonate Molarity Calculator

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Preparing Stock Solutions of Methyl tanshinonate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9555 mL 14.7776 mL 29.5552 mL 59.1104 mL 73.888 mL
5 mM 0.5911 mL 2.9555 mL 5.911 mL 11.8221 mL 14.7776 mL
10 mM 0.2956 mL 1.4778 mL 2.9555 mL 5.911 mL 7.3888 mL
50 mM 0.0591 mL 0.2956 mL 0.5911 mL 1.1822 mL 1.4778 mL
100 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.5911 mL 0.7389 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Methyl tanshinonate

Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from Salvia miltiorrhiza.[Pubmed:21412700]

Planta Med. 2011 Sep;77(14):1594-6.

In a medium throughput screen of 880 plant and fungal extracts for antiprotozoal activity, a dichloromethane extract of Salvia miltiorrhiza roots was active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. With HPLC-based activity profiling in combination with on- and off-line spectroscopic methods (PDA, -MS (n), HR-MS, microprobe NMR), the active compounds were identified as tanshinone-type diterpenoids. Subsequent isolation and structure elucidation yielded the known substances miltirone (1), tanshinone II a (2), 1,2 dihydrotanshinquinone (3), methylenetanshinquinone (4), 1-oxomiltirone (5), 11-hydroxymiltiodiol (6), tanshinone I (7), methyltanshinonate (8), and cryptotanshinone (9). The IC(5)(0)s of the compounds were determined against the two parasites and rat myoblast (L6) cells. They ranged from 4.1 microM to over 30 microM against P. falciparum K1 strain with selectivity indices (SI) from 0.3 to 1.9. IC(5)(0)s against T. brucei rhodesiense STIB 900 were from 0.5 microM (1, 4) to over 30 microM, and 4 showed the greatest selective activity with an SI of 24.

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