Nardoguaianone KCAS# 443128-65-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 443128-65-2 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C15H22O2 | M.Wt | 234.33 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Nardoguaianone K Dilution Calculator
Nardoguaianone K Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.2675 mL | 21.3374 mL | 42.6749 mL | 85.3497 mL | 106.6872 mL |
| 5 mM | 0.8535 mL | 4.2675 mL | 8.535 mL | 17.0699 mL | 21.3374 mL |
| 10 mM | 0.4267 mL | 2.1337 mL | 4.2675 mL | 8.535 mL | 10.6687 mL |
| 50 mM | 0.0853 mL | 0.4267 mL | 0.8535 mL | 1.707 mL | 2.1337 mL |
| 100 mM | 0.0427 mL | 0.2134 mL | 0.4267 mL | 0.8535 mL | 1.0669 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Terpenoids from Nardostachys jatamansi and their cytotoxic activity against human pancreatic cancer cell lines.[Pubmed:35561851]
Phytochemistry. 2022 Aug;200:113228.
Five previously unreported terpenoids, together with fifteen known analogs, were isolated from a methanol extract of the roots and rhizomes of Nardostachys jatamansi. Their structures, including absolute configurations, were elucidated by spectroscopic data and electronic circular dichroism (ECD) spectra analyses, as well as single-crystal X-ray diffraction for crystalline compounds. Structurally, (4R,5S,6S,7R)-1(10)-aristolane-8,9-diacid is a novel 8,9-dicarboxylic acid derivative of aristolane-type sesquiterpenoid. (4R,6S,7R,10S)-10-Hydroxyguaia-1(5)-6,7-epoxy-2-one is an undescribed analogue of Nardoguaianone K, with a rare 6,7-epoxide group. (4R,5R,6R,8R)-1(10)-Isonardosinone-8-ol-9-one-7,11-lactone is an isonardosinane-type sesquiterpene bearing a gamma-lactone ring. Dinardokanshone F is a rare example of a sesquiterpene dimer from N. jatamansi connected by an oxo bridge. The isolates were evaluated for their cytotoxic activity against four human pancreatic cancer cell lines (CFPAC-1, PANC-1, CAPAN-2 and SW1990). Compound epoxynardosinone exhibited significant cytotoxicity against CAPAN-2 cell lines with IC(50) value of 2.60 +/- 1.85 muM. 1-Hydroxylaristolone displayed comparable cytotoxicity on CFPAC-1 cell lines (IC(50) 1.12 +/- 1.19 muM), compared to Taxol (IC(50) 0.32 +/- 0.13 muM). 1-Hydroxylaristolone, 1(10)-aristolane-9beta-ol, 1(10)-aristolen-2-one, alpinenone, valtrate isovaleroyloxyhydrine and nardostachin displayed stronger cytotoxicity against PANC-1 cell lines with IC(50) values ranging from 0.01 +/- 0.01 to 6.50 +/- 1.10 muM. 1(10)-Aristolane-9beta-ol, 10-hydroxyguaia-1(5)-6,7-epoxy-2-one, Nardoguaianone K, nardonoxide, epoxynardosinone, 1(10)-isonardosinone-8-ol-9-one-7,11-lactone, valtrate isovaleroyloxyhydrine and nardostachin showed remarkable cytotoxicity against SW1990 cell lines with IC(50) values ranging from 0.07 +/- 0.05 to 4.82 +/- 6.96 muM. Furthermore, the primary mechanistic study of nardostachin demonstrated that it induced cell apoptosis via the mitochondria-dependent pathway, and induced SW1900 cell arrest at G2/M phase.
