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Oxysanguinarine

CAS# 548-30-1

Oxysanguinarine

2D Structure

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Oxysanguinarine: 5mg $173 In Stock
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Quality Control of Oxysanguinarine

3D structure

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Oxysanguinarine

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Chemical Properties of Oxysanguinarine

Cas No. 548-30-1 SDF Download SDF
PubChem ID 443716 Appearance Powder
Formula C20H13NO5 M.Wt 347.3
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CN1C2=C(C=CC3=CC4=C(C=C32)OCO4)C5=C(C1=O)C6=C(C=C5)OCO6
Standard InChIKey UFHGABBBZRPRJV-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H13NO5/c1-21-18-12(3-2-10-6-15-16(7-13(10)18)25-8-24-15)11-4-5-14-19(26-9-23-14)17(11)20(21)22/h2-7H,8-9H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Oxysanguinarine

The roots of Stephania epigaea

Biological Activity of Oxysanguinarine

Description1. Oxysanguinarine has potential inhibitory properties against dengue virus. 2. Oxysanguinarine possesses antiplatelet aggregation activity.
TargetsAntifection

Oxysanguinarine Dilution Calculator

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Oxysanguinarine Molarity Calculator

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Preparing Stock Solutions of Oxysanguinarine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8794 mL 14.3968 mL 28.7936 mL 57.5871 mL 71.9839 mL
5 mM 0.5759 mL 2.8794 mL 5.7587 mL 11.5174 mL 14.3968 mL
10 mM 0.2879 mL 1.4397 mL 2.8794 mL 5.7587 mL 7.1984 mL
50 mM 0.0576 mL 0.2879 mL 0.5759 mL 1.1517 mL 1.4397 mL
100 mM 0.0288 mL 0.144 mL 0.2879 mL 0.5759 mL 0.7198 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Oxysanguinarine

New tetrahydroprotoberberine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi.[Pubmed:17260290]

Planta Med. 1999 Oct;65(7):643-7.

Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and Oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropalmatine, (-)-corydalmine, (-)-scoulerine, (-)-corynoxidine, (-)-epicorynoxidine, palmatine, and protopine, have been isolated from the herb Corydalis tashiroi. The structures of these compounds were elucidated by spectroscopic analysis. Three of the isolated compounds show significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, A549, and HT-29 cell lines.

Computer-aided analysis of phytochemicals as potential dengue virus inhibitors based on molecular docking, ADMET and DFT studies.[Pubmed:29097641]

J Vector Borne Dis. 2017 Jul-Sep;54(3):255-262.

BACKGROUND & OBJECTIVES: Dengue fever, caused by dengue virus (DENV), has become a serious threat to human lives. Phytochemicals are known to have great potential to eradicate viral, bacterial and fungal-borne diseases in human beings. This study was aimed at in silico drug development against nonstructural protein 4B (NS4B) of dengue virus 4 (DENV4). METHODS: A total of 2750 phytochemicals from different medicinal plants were selected for this study. These plants grow naturally in the climate of Pakistan and India and have been used for the treatment of various pathologies in human for long-time. The ADMET studies, molecular docking and density functional theory (DFT) based analysis were carried out to determine the potential inhibitory properties of these phytochemicals. RESULTS: The ADMET analysis and docking results revealed nine phytochemicals, i.e. Silymarin, Flavobion, Derrisin, Isosilybin, Mundulinol, Silydianin, Isopomiferin, Narlumicine and Oxysanguinarine to have potential inhibitory properties against DENV and can be considered for additional in vitro and in vivo studies to assess their inhibitory effects against DENV replication. They exhibited binding affinity >/= -8 kcal/mol against DENV4-NS4B. Furthermore, DFT based analysis revealed high reactivity for these nine phytochemicals in the binding pocket of DENV4-NS4B, based on ELUMO, EHOMO and band energy gap. INTERPRETATION & CONCLUSION: Five out of nine phytochemicals are reported for the first time as novel DENV inhibitors. These included three phytochemicals from Silybum marianum, i.e. Derrisin, Mundulinol, Isopomiferin, and two phytochemicals from Fumaria indica, i.e. Narlumicine and Oxysanguinarine. However, all the nine phytochemicals can be considered for in vitro and in vivo analysis for the development of potential DENV inhibitors.

A new tetrahydroprotoberberine N-oxide alkaloid and anti-platelet aggregation constituents of Corydalis tashiroi.[Pubmed:11488455]

Planta Med. 2001 Jul;67(5):423-7.

A new tetrahydroprotoberberine N-oxide alkaloid, (-)-cis-isocorypalmine N-oxide (1), together with two known compounds, 6-methoxydihydrosanguinarine (2) and norjuziphine (3), were isolated in continuing studies of the entire Formosan Corydalis tashiroi plant. The structures of these three compounds were determined through spectral analyses. In addition, compounds 1, 2, 3 and the seven alkaloids previously reported: (-)-cis-corydalmine N-oxide, (-)-trans-corydalmine N-oxide, (-)-trans-isocorypalmine N-oxide, scoulerine, protopine, Oxysanguinarine and corydalmine, were found to possess antiplatelet aggregation activity.

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