Pinostrobin chalconeCAS# 18956-15-5 |
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| Cas No. | 18956-15-5 | SDF | Download SDF |
| PubChem ID | 5316793 | Appearance | Yellow-orange powder |
| Formula | C16H14O4 | M.Wt | 270.3 |
| Type of Compound | Chalcones | Storage | Desiccate at -20°C |
| Synonyms | Pinostrobin chalcone | ||
| Solubility | Soluble in chloroform and methan | ||
| Chemical Name | (E)-1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one | ||
| SMILES | COC1=CC(=C(C(=C1)O)C(=O)C=CC2=CC=CC=C2)O | ||
| Standard InChIKey | CUGDOWNTXKLQMD-BQYQJAHWSA-N | ||
| Standard InChI | InChI=1S/C16H14O4/c1-20-12-9-14(18)16(15(19)10-12)13(17)8-7-11-5-3-2-4-6-11/h2-10,18-19H,1H3/b8-7+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The heartwoods of Lindera umbellata.
| Description | 1. Pinostrobin chalcone displays very remarkable cytotoxic activity against the human cancer cells, such as KB, MCF7 and Caski cells (IC50 values of 6.2, 7.3 and 7.7 ug/mL, respectively). 2. Pinostrobin chalcone is a potent inhibitor of triglyceride accumulation, it can inhibit adipogenesis in 3T3-L1 cells, it may have anti-obesity effects through the inhibition of adipogenesis. |
| Targets | Fatty Acid Synthase |
Pinostrobin chalcone Dilution Calculator
Pinostrobin chalcone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.6996 mL | 18.498 mL | 36.9959 mL | 73.9919 mL | 92.4898 mL |
| 5 mM | 0.7399 mL | 3.6996 mL | 7.3992 mL | 14.7984 mL | 18.498 mL |
| 10 mM | 0.37 mL | 1.8498 mL | 3.6996 mL | 7.3992 mL | 9.249 mL |
| 50 mM | 0.074 mL | 0.37 mL | 0.7399 mL | 1.4798 mL | 1.8498 mL |
| 100 mM | 0.037 mL | 0.185 mL | 0.37 mL | 0.7399 mL | 0.9249 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Phytochemical and cytotoxic investigations of Alpinia mutica rhizomes.[Pubmed:21240148]
Molecules. 2011 Jan 14;16(1):583-9.
The methanol and fractionated extracts (hexane, ethyl acetate and water) of Alpinia mutica (Zingiberaceae) rhizomes were investigated for their cytotoxic effect against six human carcinoma cell lines, namely KB, MCF7, A549, Caski, HCT116, HT29 and non-human fibroblast cell line (MRC 5) using an in vitro cytotoxicity assay. The ethyl acetate extract possessed high inhibitory effect against KB, MCF7 and Caski cells (IC(5)(0) values of 9.4, 19.7 and 19.8 microg/mL, respectively). Flavokawin B (1), 5,6-dehydrokawain (2), Pinostrobin chalcone (3) and alpinetin (4), isolated from the active ethyl acetate extract were also evaluated for their cytotoxic activity. Of these, Pinostrobin chalcone (3) and alpinetin (4) were isolated from this plant for the first time. Pinostrobin chalcone (3) displayed very remarkable cytotoxic activity against the tested human cancer cells, such as KB, MCF7 and Caski cells (IC(5)(0) values of 6.2, 7.3 and 7.7 microg/mL, respectively). This is the first report of the cytotoxic activity of Alpinia mutica.
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