RhoifolinCAS# 17306-46-6 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 17306-46-6 | SDF | Download SDF |
PubChem ID | 5282150 | Appearance | Yellow powder |
Formula | C27H30O14 | M.Wt | 578.5 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Synonyms | Apigenin 7-O-β-D-neohesperidoside; Rhoifoloside; 4',5,7-Trihydroxyflavone 7-neohesperidoside | ||
Solubility | Soluble in methan | ||
Chemical Name | 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one | ||
SMILES | CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O | ||
Standard InChIKey | RPMNUQRUHXIGHK-PYXJVEIZSA-N | ||
Standard InChI | InChI=1S/C27H30O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-8,10,18,20-30,32-36H,9H2,1H3/t10-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Rhoifolin possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects, it may be beneficial for diabetic complications through its enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation. Rhoifolin has a radioprotective effect against radiation-induced decrease of blood platelets and cardiac biochemical lesions in whole body irradiated mice. |
Targets | GLUT | TNF-α | PGE | SOD |
In vitro | Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells.[Pubmed: 20008903]Evid Based Complement Alternat Med. 2011;2011:624375.Citrus grandis (L.) Osbeck (red wendun) leaves have been used in traditional Chinese medicine to treat several illnesses including diabetes. However, there is no scientific evidence supporting these actions and its active compounds. [Chemical constituents from Callicarpa nudiflora and their cytotoxic activities].[Pubmed: 25509294]Zhongguo Zhong Yao Za Zhi. 2014 Aug;39(16):3094-101.The chemical consitituents from cytotoxic fraction of the Callicarpa nudiflora extract were isolated and purified by a combination of HP-20 macroporous resin, silica gel and Sephadex LH-20 column chromatographies. Study on the protective effect of rhoifolin against hepatic injury induced by triptolide[Reference: WebLink]Pharmacology & Clinics of Chinese Materia Medica, 2012(6):18-20. Study on the protective effect of Rhoifolin against hepatic injury induced by triptolide. |
In vivo | Anti-inflammatory effect of Apigenin-7-neohesperidoside (Rhoifolin) in carrageenin-induced rat edema model[Reference: WebLink]J. Appl. Pharmaceut. Sci., 2012, 2(8):74-9.Flavonoids are normal constituents of the human diet and are known for a variety of biological activities. They have been reported to bring benefits in lowering inflammation and oxidative stress. |
Cell Research | Rhoifolin; A Potent Antiproliferative Effect on Cancer Cell Lines[Reference: WebLink]Brit. J. Pharmaceut. Res., 2013, 3(1):46-53.
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Animal Research | Protective Effect of Rhoifolin on Gamma Irradiation Induced Cardiac Dysfunctions in Albino Mice.[Reference: WebLink]Journal of Nuclear Science and Applications, 2014,47(1):198-204.Rhoifolin (apigenin 7 neohesperidoside) is a flavone glycoside, a natural product belonging to the flavonoid. |
Rhoifolin Dilution Calculator
Rhoifolin Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.7286 mL | 8.643 mL | 17.2861 mL | 34.5722 mL | 43.2152 mL |
5 mM | 0.3457 mL | 1.7286 mL | 3.4572 mL | 6.9144 mL | 8.643 mL |
10 mM | 0.1729 mL | 0.8643 mL | 1.7286 mL | 3.4572 mL | 4.3215 mL |
50 mM | 0.0346 mL | 0.1729 mL | 0.3457 mL | 0.6914 mL | 0.8643 mL |
100 mM | 0.0173 mL | 0.0864 mL | 0.1729 mL | 0.3457 mL | 0.4322 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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[Chemical constituents from Callicarpa nudiflora and their cytotoxic activities].[Pubmed:25509294]
Zhongguo Zhong Yao Za Zhi. 2014 Aug;39(16):3094-101.
The chemical consitituents from cytotoxic fraction of the Callicarpa nudiflora extract were isolated and purified by a combination of HP-20 macroporous resin, silica gel and Sephadex LH-20 column chromatographies. The structures were elucidated on the basis of the spectroscopic data and comparison of their spectroscopic data with reported data. The cytotoxicity was evaluated by the MTT assay. The 50% and 70% EtOH elutions of EtOH-extract showed significant cytotoxic activities, leading to the isolation of twelve compounds, which were identified as luteoloside(1), lutedin-4'-O-beta-D-glucoside(2), 6-hydroxyluteolin-7-O-beta-glucoside(3), lutedin-7-O-neohesperidoside(4), Rhoifolin (5), luteolin-7, 4'-di-O-glucoside (6), forsythoside B (7), acteoside (8), alyssonoside (9), catalpol(10), nudifloside(11), and leonuride(12). Compounds 3-6, 10 and 12 were isolated from this genus for the first time, and compound 9 was isolated from this plant for the first time. The cytotoxicity assay demonstrated that flavonoids 1-6, in various concentrations, showed monolithic proliferation inhibitory activities against Hela, A549 and MCF-7 cell lines. Compounds 3, 5 and iridoid glycoside 11 possessed higher cytotoxicacivities. In short, flavonoids are the main components of cytotoxic extract from C. nudiflora, while phenylethanoid glycosides are the predominant ingredient but inactive to cancer cell lines. In addition, the minor iridoid glycoside expressed weak cytotoxic activity.
Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells.[Pubmed:20008903]
Evid Based Complement Alternat Med. 2011;2011:624375.
Citrus grandis (L.) Osbeck (red wendun) leaves have been used in traditional Chinese medicine to treat several illnesses including diabetes. However, there is no scientific evidence supporting these actions and its active compounds. Two flavone glycosides, Rhoifolin and cosmosiin were isolated for the first time from red wendun leaves and, identified these leaves are rich source for Rhoifolin (1.1%, w/w). In differentiated 3T3-L1 adipocytes, Rhoifolin and cosmosiin showed dose-dependent response in concentration range of o.oo1-5 muM and 1-20 muM, respectively, in biological studies beneficial to diabetes. Particularly, Rhoifolin and cosmosiin at 0.5 and 20 muM, respectively showed nearly similar response to that 10 nM of insulin, on adiponectin secretion level. Furthermore, 5 muM of Rhoifolin and 20 muM of cosmosiin showed equal potential with 10 nM of insulin to increase the phosphorylation of insulin receptor-beta, in addition to their positive effect on GLUT4 translocation. These findings indicate that Rhoifolin and cosmosiin from red wendun leaves may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-beta and GLUT4 translocation.