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SR 1664

CAS# 1338259-05-4

SR 1664

Catalog No. BCC6166----Order now to get a substantial discount!

Product Name & Size Price Stock
SR 1664: 5mg $115 In Stock
SR 1664: 10mg Please Inquire In Stock
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Chemical structure

SR 1664

3D structure

Chemical Properties of SR 1664

Cas No. 1338259-05-4 SDF Download SDF
PubChem ID 53239854 Appearance Powder
Formula C33H29N3O5 M.Wt 547.6
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
Chemical Name 2-[4-[[2,3-dimethyl-5-[[(1S)-1-(4-nitrophenyl)ethyl]carbamoyl]indol-1-yl]methyl]phenyl]benzoic acid
SMILES CC1=C(N(C2=C1C=C(C=C2)C(=O)NC(C)C3=CC=C(C=C3)[N+](=O)[O-])CC4=CC=C(C=C4)C5=CC=CC=C5C(=O)O)C
Standard InChIKey IIJDFXNUWZTHIM-NRFANRHFSA-N
Standard InChI InChI=1S/C33H29N3O5/c1-20-22(3)35(19-23-8-10-25(11-9-23)28-6-4-5-7-29(28)33(38)39)31-17-14-26(18-30(20)31)32(37)34-21(2)24-12-15-27(16-13-24)36(40)41/h4-18,21H,19H2,1-3H3,(H,34,37)(H,38,39)/t21-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of SR 1664

DescriptionAntidiabetic agent; binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity. Does not inhibit Cdk5-dependent phosphorylation of Rb. Reduces fasting insulin levels and improves insulin sensitivity in a mouse model of diabetes.

SR 1664 Dilution Calculator

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SR 1664 Molarity Calculator

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Preparing Stock Solutions of SR 1664

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8262 mL 9.1308 mL 18.2615 mL 36.523 mL 45.6538 mL
5 mM 0.3652 mL 1.8262 mL 3.6523 mL 7.3046 mL 9.1308 mL
10 mM 0.1826 mL 0.9131 mL 1.8262 mL 3.6523 mL 4.5654 mL
50 mM 0.0365 mL 0.1826 mL 0.3652 mL 0.7305 mL 0.9131 mL
100 mM 0.0183 mL 0.0913 mL 0.1826 mL 0.3652 mL 0.4565 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on SR 1664

Antidiabetic actions of a non-agonist PPARgamma ligand blocking Cdk5-mediated phosphorylation.[Pubmed:21892191]

Nature. 2011 Sep 4;477(7365):477-81.

PPARgamma is the functioning receptor for the thiazolidinedione (TZD) class of antidiabetes drugs including rosiglitazone and pioglitazone. These drugs are full classical agonists for this nuclear receptor, but recent data have shown that many PPARgamma-based drugs have a separate biochemical activity, blocking the obesity-linked phosphorylation of PPARgamma by Cdk5. Here we describe novel synthetic compounds that have a unique mode of binding to PPARgamma, completely lack classical transcriptional agonism and block the Cdk5-mediated phosphorylation in cultured adipocytes and in insulin-resistant mice. Moreover, one such compound, SR1664, has potent antidiabetic activity while not causing the fluid retention and weight gain that are serious side effects of many of the PPARgamma drugs. Unlike TZDs, SR1664 also does not interfere with bone formation in culture. These data illustrate that new classes of antidiabetes drugs can be developed by specifically targeting the Cdk5-mediated phosphorylation of PPARgamma.

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