PPAR
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
Products for PPAR
- Cat.No. Product Name Information
- BCC1337 AleglitazarPPARα/PPARγagonist
- BCC1395 BalaglitazonePPAR-γ partial agonist
- BCC1611 GW1929Potent PPARγ agonist
- BCC1652 InolitazonePPARgamma agonist
- BCC1653 Inolitazone dihydrochloridePPARγ agonist,high-affinity and novel
- BCC1687 L-165041PPARβ/δ agonist,cell permeable,potent and selective
- BCC2016 TroglitazoneSelective PPARγ agonist
- BCC2260 GW9662PPARγ antagonist
- BCC2261 T0070907Human PPARγ antagonist,potent and selective
- BCC2262 Rosiglitazone maleatePPARγ agonist,high-affinity and selective,potent insulin sensitizer
- BCC2263 GSK3787PPARβ/δ antagonist,novel and irreversible
- BCC2264 RosiglitazonePromotes differentiation of adipocytes; also potent and selective PPARγ agonist
- BCC2265 WY-14643 (Pirinixic Acid)PPARα agonist,selective and highly potent
- BCC2266 Ciprofibrate
- BCC2267 GW0742PPARδ/β agonist,potent and selective
- BCC2268 GW501516PPARβ agonist,selective and potent
- BCC2269 Rosiglitazone HCl
- BCC2278 Pioglitazone HClPPARγ agonist
- BCC4023 AUDA
- BCC4781 Fenofibrate
- BCC4783 Gemfibrozil
- BCC4927 Pioglitazone
- BCC5308 ClofibratePPAR agonist
- BCC6166 SR 1664
- BCC7014 Ciglitazone
- BCC7022 BADGE
- BCC7150 GW 7647
- BCC7243 SR 202PPAR antagonist
- BCC7268 nTZDpa
- BCC7321 15-deoxy-Δ-12,14-Prostaglandin J2
- BCC7688 GSK 0660
- BCC7751 S26948
- BCC7828 Tesaglitazar
- BCC7881 CP 775146