TC LPA5 4LPA5 receptor antagonist CAS# 1393814-38-4 |
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Quality Control & MSDS
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| Cas No. | 1393814-38-4 | SDF | Download SDF |
| PubChem ID | 66552906 | Appearance | Powder |
| Formula | C23H23ClN2O3 | M.Wt | 410.89 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO | ||
| Chemical Name | 5-(3-chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)pyrazole-3-carboxylic acid | ||
| SMILES | COC1=CC=CC(=C1)N2C(=CC(=N2)C(=O)O)C3=CC(=C(C=C3)C4CCCCC4)Cl | ||
| Standard InChIKey | BNALUYKEGYUHQC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H23ClN2O3/c1-29-18-9-5-8-17(13-18)26-22(14-21(25-26)23(27)28)16-10-11-19(20(24)12-16)15-6-3-2-4-7-15/h5,8-15H,2-4,6-7H2,1H3,(H,27,28) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells). Inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA5 against 80 other screened targets. |
TC LPA5 4 Dilution Calculator
TC LPA5 4 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4337 mL | 12.1687 mL | 24.3374 mL | 48.6748 mL | 60.8435 mL |
| 5 mM | 0.4867 mL | 2.4337 mL | 4.8675 mL | 9.735 mL | 12.1687 mL |
| 10 mM | 0.2434 mL | 1.2169 mL | 2.4337 mL | 4.8675 mL | 6.0844 mL |
| 50 mM | 0.0487 mL | 0.2434 mL | 0.4867 mL | 0.9735 mL | 1.2169 mL |
| 100 mM | 0.0243 mL | 0.1217 mL | 0.2434 mL | 0.4867 mL | 0.6084 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Selective non-lipid modulator of LPA5 activity in human platelets.[Pubmed:22801643]
Bioorg Med Chem Lett. 2012 Aug 15;22(16):5239-43.
Lysophosphatidic acid (LPA) is a potent activator of human platelets in vitro. Recently, the G protein-coupled receptor LPA5/GPR92 has been identified to be the relevant LPA receptor responsible for the activation of human platelets by LPA. In a high-throughput screening campaign we identified a diphenyl pyrazole carboxylic acid as a small-molecule inhibitor for LPA5. Confirmation for the specificity of this small molecule was achieved in human platelets as the relevant cellular in vitro model. We could confirm using antagonists for alternative LPA receptors that we identified in our work the first non-lipid, small-molecule inhibitor for LPA5/GPR92 specifically inhibiting LPA-mediated platelet activation in vitro.
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