TC-N 22APotent, selective mGlu4 positive allosteric modulator CAS# 1314140-00-5 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 1314140-00-5 | SDF | Download SDF |
| PubChem ID | 46836562 | Appearance | Powder |
| Formula | C14H13N5S | M.Wt | 283.35 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 50 mM in DMSO | ||
| Chemical Name | N-pyridin-2-yl-4,5,6,7-tetrahydropyrazolo[2,3]cyclohepta[2,4-b][1,3]thiazol-2-amine | ||
| SMILES | C1CC2=C(C=NN2)C3=C(C1)SC(=N3)NC4=CC=CC=N4 | ||
| Standard InChIKey | DBISXWCOHGUFSF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H13N5S/c1-2-7-15-12(6-1)17-14-18-13-9-8-16-19-10(9)4-3-5-11(13)20-14/h1-2,6-8H,3-5H2,(H,16,19)(H,15,17,18) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant. |
TC-N 22A Dilution Calculator
TC-N 22A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5292 mL | 17.646 mL | 35.292 mL | 70.5841 mL | 88.2301 mL |
| 5 mM | 0.7058 mL | 3.5292 mL | 7.0584 mL | 14.1168 mL | 17.646 mL |
| 10 mM | 0.3529 mL | 1.7646 mL | 3.5292 mL | 7.0584 mL | 8.823 mL |
| 50 mM | 0.0706 mL | 0.3529 mL | 0.7058 mL | 1.4117 mL | 1.7646 mL |
| 100 mM | 0.0353 mL | 0.1765 mL | 0.3529 mL | 0.7058 mL | 0.8823 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.[Pubmed:21688779]
J Med Chem. 2011 Jul 28;54(14):5070-81.
There is an increasing amount of evidence to support that activation of the metabotropic glutamate receptor 4 (mGlu4 receptor), either with an orthosteric agonist or a positive allosteric modulator (PAM), provides impactful interventions in diseases such as Parkinson's disease, anxiety, and pain. mGlu4 PAMs may have several advantages over mGlu4 agonists for a number of reasons. As part of our efforts in identifying therapeutics for central nervous system (CNS) diseases such as Parkinson's disease, we have been focusing on metabotropic glutamate receptors. Herein we report our studies with a series of tricyclic thiazolopyrazoles as mGlu4 PAMs.
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