PDZ1 Domain inhibitor peptideDisrupts interaction between GluR6 and PSD-95 PDZ1 domain CAS# 1315378-73-4 |
Related Products
- GSK2334470
Catalog No.:BCC4982
CAS No.:1227911-45-6
- BX-912
Catalog No.:BCC1250
CAS No.:702674-56-4
- OSU-03012 (AR-12)
Catalog No.:BCC1255
CAS No.:742112-33-0
- NVP-BAG956
Catalog No.:BCC1813
CAS No.:853910-02-8
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1315378-73-4 | SDF | Download SDF |
| PubChem ID | 90488746 | Appearance | Powder |
| Formula | C38H61N9O11 | M.Wt | 819.95 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 1 mg/ml in 5% acetonitrile / water and to 4 mg/ml in DMSO | ||
| Sequence | YKKTEAV (Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6)) | ||
| Chemical Name | (2S)-2-[[(2S)-2-[[(2S,5S,14S)-14-[[(2S)-6-amino-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-2-[(1R)-1-hydroxyethyl]-3,8,15-trioxo-1,4,9-triazacyclopentadecane-5-carbonyl]amino]propanoyl]amino]-3-methylbutanoic acid | ||
| SMILES | CC(C)C(C(=O)O)NC(=O)C(C)NC(=O)C1CCC(=O)NCCCCC(C(=O)NC(C(=O)N1)C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CC=C(C=C2)O)N | ||
| Standard InChIKey | XXRRADBJCXMGOW-RMLJCASOSA-N | ||
| Standard InChI | InChI=1S/C38H61N9O11/c1-20(2)30(38(57)58)46-32(51)21(3)42-34(53)28-15-16-29(50)41-18-8-6-10-27(36(55)47-31(22(4)48)37(56)45-28)44-35(54)26(9-5-7-17-39)43-33(52)25(40)19-23-11-13-24(49)14-12-23/h11-14,20-22,25-28,30-31,48-49H,5-10,15-19,39-40H2,1-4H3,(H,41,50)(H,42,53)(H,43,52)(H,44,54)(H,45,56)(H,46,51)(H,47,55)(H,57,58)/t21-,22+,25-,26-,27-,28-,30-,31-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Novel cyclic peptide that disrupts interaction between GluK2 (formerlyy GluR6) and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluK2 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors. |
PDZ1 Domain inhibitor peptide Dilution Calculator
PDZ1 Domain inhibitor peptide Molarity Calculator
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- Scrambled 10Panx
Catalog No.:BCC1246
CAS No.:1315378-72-3
- TCS 184
Catalog No.:BCC5899
CAS No.:1315378-71-2
- pep2-AVKI
Catalog No.:BCC5787
CAS No.:1315378-69-8
- pep2-EVKI
Catalog No.:BCC5786
CAS No.:1315378-67-6
- NG25
Catalog No.:BCC1799
CAS No.:1315355-93-1
- B-Raf inhibitor
Catalog No.:BCC1437
CAS No.:1315330-11-0
- HG6-64-1
Catalog No.:BCC5459
CAS No.:1315329-43-1
- TMP269
Catalog No.:BCC3993
CAS No.:1314890-29-3
- Amyloid Beta-Peptide (1-40) (human)
Catalog No.:BCC1045
CAS No.:131438-79-4
- Cercosporamide
Catalog No.:BCC2438
CAS No.:131436-22-1
- UNC669
Catalog No.:BCC3997
CAS No.:1314241-44-5
- TC-N 22A
Catalog No.:BCC6150
CAS No.:1314140-00-5
New Products
- Bax inhibitor peptide, negative control
Catalog No.:BCC2395
CAS No.:1315378-74-5
- MNI caged kainic acid
Catalog No.:BCC7297
CAS No.:1315378-75-6
- pep2-SVKE
Catalog No.:BCC5785
CAS No.:1315378-76-7
- Rac1 Inhibitor F56, control peptide
Catalog No.:BCC5887
CAS No.:1315378-77-8
- NPEC-caged-(1S,3R)-ACPD
Catalog No.:BCC7653
CAS No.:1315379-60-2
- VU 591 hydrochloride
Catalog No.:BCC6126
CAS No.:1315380-70-1
- Triumbelletin
Catalog No.:BCN6779
CAS No.:131559-54-1
- Camelliaside B
Catalog No.:BCN3872
CAS No.:131573-90-5
- Calystegine A3
Catalog No.:BCN1884
CAS No.:131580-36-4
- Betulinaldehyde
Catalog No.:BCN1249
CAS No.:13159-28-9
- Amyloid Beta-peptide (25-35) (human)
Catalog No.:BCC1027
CAS No.:131602-53-4
- (+)-Pteryxin
Catalog No.:BCN3470
CAS No.:13161-75-6
Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide.[Pubmed:15123241]
Chem Biol. 2004 Apr;11(4):469-73.
A cyclic peptide, Tyr-Lys-c[-Lys-Thr-Glu(betaAla)-]-Val, incorporating a beta-Ala lactam side chain linker and designed to target the PDZ domains of the postsynaptic density protein 95 (PSD-95), has been synthesized and structurally characterized by NMR while free and bound to the PDZ1 domain of PSD-95. While bound, the lactam linker of the peptide makes a number of unique contacts outside the canonical PDZ binding motif, providing a novel target for PDZ-domain specificity as well as producing a 10-fold enhancement in binding affinity. Additionally, the cyclization greatly enhances the enzymatic stability, increasing the duration that the peptide inhibits the association between PSD-95 and glutamate receptors, effectively inhibiting the clustering of kainate receptors for over 14 hr after application. Highly specific regulation of kainate receptor action may provide a novel route for treatment of drug addiction and epilepsy.
PDZ1 Domain inhibitor peptide,1315378-73-4,Natural Products,Kainate Receptors, buy PDZ1 Domain inhibitor peptide , PDZ1 Domain inhibitor peptide supplier , purchase PDZ1 Domain inhibitor peptide , PDZ1 Domain inhibitor peptide cost , PDZ1 Domain inhibitor peptide manufacturer , order PDZ1 Domain inhibitor peptide , high purity PDZ1 Domain inhibitor peptide
