Usaramine

CAS# 15503-87-4

Usaramine

Catalog No. BCN2121----Order now to get a substantial discount!

Product Name & Size Price Stock
Usaramine: 5mg $58 In Stock
Usaramine: 10mg Please Inquire In Stock
Usaramine: 20mg Please Inquire Please Inquire
Usaramine: 50mg Please Inquire Please Inquire
Usaramine: 100mg Please Inquire Please Inquire
Usaramine: 200mg Please Inquire Please Inquire
Usaramine: 500mg Please Inquire Please Inquire
Usaramine: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Usaramine

Number of papers citing our products

Chemical structure

Usaramine

3D structure

Chemical Properties of Usaramine

Cas No. 15503-87-4 SDF Download SDF
PubChem ID 5281756 Appearance White powder
Formula C18H25NO6 M.Wt 351.40
Type of Compound Alkaloids Storage Desiccate at -20°C
Synonyms Mucronatine; trans-Retrorsine
Solubility Soluble in chloroform
SMILES CC=C1CC(C(C(=O)OCC2=CCN3C2C(CC3)OC1=O)(CO)O)C
Standard InChIKey BCJMNZRQJAVDLD-FXGRWVCYSA-N
Standard InChI InChI=1S/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3+/t11-,14-,15-,18-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Usaramine

1 Senecio sp.

Biological Activity of Usaramine

DescriptionUsaramine may have hepatotoxic.
In vitro

Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang).[Reference: WebLink]

Rapid communications in mass spectrometry : RCM, 2008, 22(4):591-602.

Senecio scandens Buch.-Ham is a plant source for a commonly used traditional Chinese medicinal (TCM) herb Qianliguang. A TCM herbal proprietary product containing Qianliguang as the major herb for the treatment of sinusitis has been used in China for several decades, and has also been exported to other regions and countries worldwide.
METHODS AND RESULTS:
In the present study, the aqueous extract of S. scandens collected in the Shanxi Province of China was determined, for the first time, to contain hepatotoxic and tumorigenic pyrrolizidine alkaloids (PAs) by using high-performance liquid chromatography/mass spectrometric (HPLC/MS) analysis in various scanning modes. A total of nine toxic and two non-toxic PAs were detected in the aqueous extract of S. scandens, of which six PAs, namely neoplatyphylline, senecionine, senecionine N-oxide, seneciphylline, seneciphylline N-oxide and senkirkine, were unequivocally characterized, while other PAs were tentatively assigned as jacobine, jacozine N-oxide (or erucifoline N-oxide), 7-tigloylplatynecine, Usaramine and an isomer of yamataimine. The estimated total content of toxic PAs in S. scandens was 10.82 microg/g herb, which was significantly higher than that (> or =1 microg/g herb) recommended by Belgium and Germany not to be used clinically. Among the PAs definitively identified, senecionine, seneciphylline, and senkirkine are known tumorigens capable of inducing liver tumors in experimental animals, while seneciphylline N-oxide and senecionine N-oxide are probably tumorigenic due to their potential conversion into seneciphylline and senecionine via metabolic reduction in the body.
CONCLUSIONS:
Thus, the current finding of the presence of toxic/tumorigenic PAs in S. scandens challenges the safety of using this TCM herb and its proprietary products.

Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae).[Reference: WebLink]

Journal of Ethnopharmacology, 1994, 43(1):19-30.

A study of the hepatotoxic pyrrolizidine alkaloids (PAs) contained in Packera candidissima (Greene) Weber & Löve (Senecio candidissimus Greene), a Mexican medicinal plant used for the treatment of kidney ailments and noted for its antiseptic properties, is reported.
METHODS AND RESULTS:
Analysis by TLC and GC-MS have shown the presence in high levels of both PAs and their N-oxides in the root (0.76% dry weight) and the aerial parts (0.36% dry weight) of the plant material. GC-MS analysis showed the presence of senecionine, integerrimine, retrorsine, and Usaramine in the aerial parts. The root was found to contain senkirkine as the major component.
CONCLUSIONS:
These results indicate that users of this herb are at high risk of poisoning, especially members of certain cultural groups in Northern Mexico and the Hispanic population in the southwestern United States. In addition, two sesquiterpenes, neoadenostylone and epineoadenostylone were identified from the neutral extracts of this plant material. The 6α-angeloyloxy-9-oxo-Δ10(1)-furanoeremophilane is reported for the first time as a natural product.

Protocol of Usaramine

Structure Identification
Australian Journal of Chemistry, 1966, 19(11):2127-2131.

Usaramine, a New Pyrrolizidine Alkaloid from Crotalaria Usaarmoensis E. G. Baker.[Reference: WebLink]


METHODS AND RESULTS:
The major alkaloid, Usaramine, of the seed of C. usaramoensis E. G. Baker, is shown to be the geometric isomer of retrorsine; i.e. an ester of retronecine with retronecic acid.
CONCLUSIONS:
Other alkaloids in the seed are integerrimine, traces of senecionine and retrorsine, and two unidentified non-ester bases. The previously reported usaramoensine1 was not detected and is considered to be a mixture.

Usaramine Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Usaramine Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Usaramine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8458 mL 14.2288 mL 28.4576 mL 56.9152 mL 71.144 mL
5 mM 0.5692 mL 2.8458 mL 5.6915 mL 11.383 mL 14.2288 mL
10 mM 0.2846 mL 1.4229 mL 2.8458 mL 5.6915 mL 7.1144 mL
50 mM 0.0569 mL 0.2846 mL 0.5692 mL 1.1383 mL 1.4229 mL
100 mM 0.0285 mL 0.1423 mL 0.2846 mL 0.5692 mL 0.7114 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

Description

Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria.

Keywords:

Usaramine,15503-87-4,Mucronatine; trans-Retrorsine,Natural Products, buy Usaramine , Usaramine supplier , purchase Usaramine , Usaramine cost , Usaramine manufacturer , order Usaramine , high purity Usaramine

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: