Spartioidine

CAS# 520-59-2

Spartioidine

2D Structure

Catalog No. BCN2134----Order now to get a substantial discount!

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Quality Control of Spartioidine

3D structure

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Spartioidine

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Chemical Properties of Spartioidine

Cas No. 520-59-2 SDF Download SDF
PubChem ID 6438237 Appearance Powder
Formula C18H23NO5 M.Wt 333.38
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC=C1CC(=C)C(C(=O)OCC2=CCN3C2C(CC3)OC1=O)(C)O
Standard InChIKey FCEVNJIUIMLVML-DVZMFYIRSA-N
Standard InChI InChI=1S/C18H23NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,14-15,22H,2,6-10H2,1,3H3/b12-4+/t14-,15-,18+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Spartioidine

The herbs of Senecio pterophorus.

Biological Activity of Spartioidine

In vitro

Pyrrolizidine Alkaloids in Adenostyles alliariae and A. glabra from the Austrian Alps.[Pubmed: 26411004]

Nat Prod Commun. 2015 Jul;10(7):1179-80.

The alkaloid content of Adenostyles alliariae and A. glabra (Asteraceae) has been evaluated.
METHODS AND RESULTS:
Both species contain toxic macrocyclic unsaturated pyrrolizidine alkaloids with seneciphylline as the main compound accounting for more than 90% of the alkaloid fraction in all above ground plant parts. Further alkaloids were Spartioidine, acetyl-senciphylline and senecionine. Inflorescences showed the highest alkaloid contents with 21.1 and 13.4 mg/g in A. alliariae and A. glabra, respectively. Stems and leaves had 2-3 times lower contents.
CONCLUSIONS:
Therefore, these Adenostyles species must be considered as highly toxic plants.

Protocol of Spartioidine

Structure Identification
Phytochemistry,1993,34(6):1629–1631.

A re-investigation of the alkaloids of Senecio pterophorus[Reference: WebLink]


METHODS AND RESULTS:
The known pyrrolizidine alkaloids seneciphylline, Spartioidine, acetylseneciphylline, senecionine, and rosmarinine have been isolated from Senecio pterophorus along with a new alkaloid, for which the name isorosmarinine is proposed.

Fitoterapia. 2002 Apr;73(2):171-3.

Alkaloids from Senecio aquaticus.[Pubmed: 11978435]

Erucifoline (1) and 9-angeloylhastanecine (2) were isolated from the aerial parts of Senecio aquaticus.
METHODS AND RESULTS:
Five other pyrrolizidine alkaloids were tentatively identified by GC/MS analysis: jacobine; seneciphylline; Spartioidine; jacozine; and senecionine.

Spartioidine Dilution Calculator

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Spartioidine Molarity Calculator

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Preparing Stock Solutions of Spartioidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9996 mL 14.9979 mL 29.9958 mL 59.9916 mL 74.9895 mL
5 mM 0.5999 mL 2.9996 mL 5.9992 mL 11.9983 mL 14.9979 mL
10 mM 0.3 mL 1.4998 mL 2.9996 mL 5.9992 mL 7.499 mL
50 mM 0.06 mL 0.3 mL 0.5999 mL 1.1998 mL 1.4998 mL
100 mM 0.03 mL 0.15 mL 0.3 mL 0.5999 mL 0.7499 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Spartioidine

Alkaloids from Senecio aquaticus.[Pubmed:11978435]

Fitoterapia. 2002 Apr;73(2):171-3.

Erucifoline (1) and 9-angeloylhastanecine (2) were isolated from the aerial parts of Senecio aquaticus. Five other pyrrolizidine alkaloids were tentatively identified by GC/MS analysis: jacobine; seneciphylline; Spartioidine; jacozine; and senecionine.

Pyrrolizidine Alkaloids in Adenostyles alliariae and A. glabra from the Austrian Alps.[Pubmed:26411004]

Nat Prod Commun. 2015 Jul;10(7):1179-80.

The alkaloid content of Adenostyles alliariae and A. glabra (Asteraceae) has been evaluated. Both species contain toxic macrocyclic unsaturated pyrrolizidine alkaloids with seneciphylline as the main compound accounting for more than 90% of the alkaloid fraction in all above ground plant parts. Further alkaloids were Spartioidine, acetyl-senciphylline and senecionine. Inflorescences showed the highest alkaloid contents with 21.1 and 13.4 mg/g in A. alliariae and A. glabra, respectively. Stems and leaves had 2-3 times lower contents. Therefore, these Adenostyles species must be considered as highly toxic plants.

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