Cancer Research

Cancer is a term used to define a group of diseases in which abnormal cells divide without control, are able to invade neighboring tissues/organs and metastasize. Cancer has been characterized by six hallmarks; self sufficiency in proliferative growth signals, insensitivity to growth inhibitors, evasion of apoptosis, limitless replicative potential, ability to develop blood vessels (angiogenesis), and tissue invasion and metastasis.

Cancer Research Products Areas

Products for Cancer Research - Page 10

Cat.No. Product Name Information/Activity
BCC5580 BMH-21 BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription; does not cause phosphorylation of H2AX.
BCC2406 CP 31398 dihydrochloride p53-stabilizing agent
BCC2409 MIRA-1 Restores mutant p53 activity; proapoptotic
BCC2411 PhiKan 083 PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells.
BCC2413 PRIMA-1 PRIMA-1 (NSC-281668) is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.
BCC2414 PRIMA-1MET PRIMA-1Met restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1Met also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.
BCC6131 SCH 529074 922150-11-6
BCC2399 Cesium chloride Potassium channel blocker; neuroprotective
BCC3911 CGK733 CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer.
BCC2400 DAPK Substrate Peptide Death associated protein kinase substrate (synthetic)