Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 49

  1. Cat.No. Product Name Information/Activity
  2. BCC6781 Clobenpropit dihydrobromide Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC50 of 8.07 for histamine H3LR. Clobenpropit dihydrobromide acts as partial agonist at histamine H4 receptors (Ki 13 nM). Clobenpropit dihydrobromide also binds to serotonin 5-HT3 receptors (Ki 7.4 nM) and α2A/α2C adrenoceptors (Ki 17.4/7.8 nM). Clobenpropit dihydrobromide increases apoptosis. Clobenpropit dihydrobromide chemical structure
  3. BCC7352 Conessine 546-06-5 Conessine chemical structure
  4. BCC7357 GT 2016 152241-24-2 GT 2016 chemical structure
  5. BCC7197 Impentamine dihydrobromide 149629-70-9 Impentamine dihydrobromide chemical structure
  6. BCC6793 Iodophenpropit dihydrobromide Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM). Iodophenpropit dihydrobromide chemical structure
  7. BCC7842 JNJ 10181457 dihydrochloride 544707-20-2 JNJ 10181457 dihydrochloride chemical structure
  8. BCC6101 JNJ 5207852 dihydrochloride JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively. JNJ 5207852 dihydrochloride chemical structure
  9. BCC7245 ROS 234 dioxalate 184576-87-2 ROS 234 dioxalate chemical structure
  10. BCC6182 SEN 12333 874450-44-9 SEN 12333 chemical structure
  11. BCC6734 Thioperamide 106243-16-7 Thioperamide chemical structure

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